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Latent Kaposi’s sarcoma-associated herpesvirus infection in bladder cancer cells promotes drug resistance by reducing reactive oxygen species

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Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major etiologic agent of Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. Recent studies have indicated that KSHV can be detected at high frequency in patient-derived bladder cancer tissue and might be associated with the pathogenesis of bladder cancer. Bladder cancer is the second most common cancer of the genitourinary tract, and it has a high rate of recurrence. Because drug resistance is closely related to chemotherapy failure and cancer recurrence, we investigated whether KSHV infection is associated with drug resistance of bladder cancer cells. Some KSHV-infected bladder cancer cell lines showed resistance to an anti-cancer drug, cisplatin, possibly as a result of down-regulation of reactive oxygen species. Additionally, drug resistance acquired from KSHV infection could partly be overcome by HDAC1 inhibitors. Taken together, the data suggest the possible role of KSHV in chemo-resistant bladder cancer, and indicate the therapeutic potential of HDAC1 inhibitors in drug-resistant bladder cancers associated with KSHV infection.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, 34824, Republic of Korea

    Suhyuk Lee, Jaehyuk Jang, Hyungtaek Jeon, Jisu Lee, Seung-Min Yoo & Myung-Shin Lee

  2. Department of Urology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, 34824, Republic of Korea

    Jinsung Park

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  1. Suhyuk Lee
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  2. Jaehyuk Jang
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  3. Hyungtaek Jeon
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  4. Jisu Lee
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  5. Seung-Min Yoo
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Correspondence to Myung-Shin Lee.

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Lee, S., Jang, J., Jeon, H. et al. Latent Kaposi’s sarcoma-associated herpesvirus infection in bladder cancer cells promotes drug resistance by reducing reactive oxygen species. J Microbiol. 54, 782–788 (2016). https://doi.org/10.1007/s12275-016-6388-x

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