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Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

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Abstract

Multimodal combinatorial therapy merges different modes of therapies in one platform, which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency. Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy. By super-assembly of mesoporous silica nanoparticles (MSN) with metal-phenolic networks (MPN), anti-cancer drugs can be loaded in the MSN matrix, while the outer MPN coating allows dual photothermal and pH-responsive properties. Upon near-infrared light irradiation, the MSN@MPN nanoplatform exhibits excellent photothermal effect, and demonstrates outstanding pH-triggered drug release property. In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs. Consequently, the MSN@MPN system shows promising prospects in clinical application for tumor therapy.

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Acknowledgements

This work was supported by the National Key Research and Development Program of China (Nos. 2019YFC1604600, 2017YFA0206901, 2017YFA0206900), the National Natural Science Foundation of China (Nos. 21705027, 21974029, and 81830052), the Construction project of Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Shanghai Municipal Education Commission (Class II Plateau Disciplinary Construction Program of Medical Technology of SUMHS, 2018–2020), the Australia National Health and Medical Research Council (NHMRC) (No. APP1163786), the Scientia Fellowship program at UNSW, the MCTL Visiting Fellowship Program, Shanghai Key Laboratory of Molecular Imaging (No. 18DZ2260400), the Natural Science Foundation of Shanghai, and the Recruitment Program of Global Experts of China and Shanghai.

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Authors and Affiliations

  1. Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, iChEM, Fudan University, Shanghai, 200032, China

    Bo Yang, Shan Zhou, Jie Zeng, Liping Zhang, Runhao Zhang, Lei Xie, Dongyuan Zhao & Biao Kong

  2. School of Chemical Engineering and Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, NSW, 2052, Australia

    Kang Liang

  3. Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China

    Bing Shao

  4. Department of Nuclear Medicine, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China

    Shaoli Song

  5. Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China

    Gang Huang

  6. Institute of Clinical Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China

    Gang Huang

  7. Department of Chemical Engineering, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada

    Pu Chen

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  1. Bo Yang
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  2. Shan Zhou
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  3. Jie Zeng
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  10. Gang Huang
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  13. Biao Kong
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Correspondence to Biao Kong.

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Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy

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Yang, B., Zhou, S., Zeng, J. et al. Super-assembled core-shell mesoporous silica-metal-phenolic network nanoparticles for combinatorial photothermal therapy and chemotherapy. Nano Res. 13, 1013–1019 (2020). https://doi.org/10.1007/s12274-020-2736-6

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