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Chemical constituents from the leaves of Juglans mandshurica

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Abstract

Two new (1 and 3) and two known diarylheptanoids (2 and 4), along with two tetralones (5 and 6), one naphthoquinone (7), four phenylpropanoids (8–11), and one phenol (12) were isolated from the leaves of Juglans mandshurica. Their structures were elucidated on the basis of spectral and chemical data. Compounds 2 and 10 are firstly isolated from this plant and 8 and 12 were isolated from the Juglans genus for the first time. Among these compounds, only 7 exhibited moderate cytotoxicities against cultured MGC-803, A549, K562, and HeLa tumor cell lines with IC50 values of 25.90, 28.60, 39.06, 44.90 μM, respectively.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China under Grant Numbers 30760291, 81160386, and 30911140276.

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Authors and Affiliations

  1. Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People’s Republic of China

    Da Lei Yao, Chang Hao Zhang, Jie Luo, Mei Jin, Ming Shan Zheng, Jiong Mo Cui & Gao Li

  2. Yanbian University Hospital, Yanji, 133000, China

    Mei Jin

  3. College of Pharmacy, Yeungnam University, Gyeongsan, 712-749, Korea

    Jong Keun Son

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  1. Da Lei Yao
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  2. Chang Hao Zhang
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  3. Jie Luo
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  4. Mei Jin
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  5. Ming Shan Zheng
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  6. Jiong Mo Cui
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  8. Gao Li
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Corresponding author

Correspondence to Gao Li.

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Da Lei Yao and Chang Hao Zhang contributed equally to this study.

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Yao, D.L., Zhang, C.H., Luo, J. et al. Chemical constituents from the leaves of Juglans mandshurica . Arch. Pharm. Res. 38, 480–484 (2015). https://doi.org/10.1007/s12272-014-0398-1

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  • DOI: https://doi.org/10.1007/s12272-014-0398-1

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