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Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

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Abstract

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.

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Acknowledgments

We sincerely thank and acknowledge Higher Education Commission (HEC) of Pakistan for financial support.

Conflict of Interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan

    Gowhar Ali, Fazal Subhan, Muhammad Shahid, Sami Ullah, Ihsan Ullah & Rehmat Shah

  2. Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan

    Nazar Ul Islam, Nasir Ullah & Ikhtiar Khan

  3. Sarhad University of Sciences and Information Technology, Peshawar, 25000, Pakistan

    Nazar Ul Islam

  4. Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Ave., Cardiff, CF10 3NB, UK

    Robert D. E. Sewell

  5. Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan

    Ghulam Abbas

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  1. Gowhar Ali
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Correspondence to Gowhar Ali.

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Ali, G., Subhan, F., Islam, N.U. et al. Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study. Arch. Pharm. Res. 37, 916–926 (2014). https://doi.org/10.1007/s12272-013-0245-9

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