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Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes

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Abstract

A new prenylated dihydroflavonol, 3-hydroxy-kenusanone B 1, as well as three other known isoflavanones, sophoronol 2, sophoraisoflavanone A 3 and kenusanone H 4, were isolated from the rhizomes of Echinosophora koreensis. The structures of these compounds were elucidated using spectroscopic analyses that included extensive 2D NMR, optical rotation spectrometry and mass spectrometry. All four flavonoids enhanced the activities of alcohol metabolizing enzymes such as alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) at micromolar concentrations. Sophoronol 2 showed a nine-fold increased activation of alcohol dehydrogenase and aldehyde dehydrogenase than a negative control group at concentrations of 100 μg/mL and 50 μg/mL, respectively. This study suggests that prenylated flavonoids have the potential to prevent ‘hangovers’ after alcohol intake.

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Authors and Affiliations

  1. Korea Institute of Science and Technology, Gangneung Institute, Gangneung, 210-340, Korea

    Eun Ju Choi, Hak Cheol Kwon, Hyun Bong Park, Cheol Young Kim & Hyun Ok Yang

  2. Faculty of Marine Bioscience and Technology, Kangnung-Wonju National University, Gangneung, 210-702, Korea

    Eun Ju Choi & Young Chang Sohn

  3. National Institute of Highland Agriculture, Pyeongchang, 232-955, Korea

    Chun Woo Nam

  4. Faculty of Natural Science, Kangnung-Wonju National University, Gangneung, 210-702, Korea

    Hyun Bong Park

  5. KIST Gangneung Institute, Gangneung, 210-340, Korea

    Hyun Ok Yang

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  1. Eun Ju Choi
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  2. Hak Cheol Kwon
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  3. Young Chang Sohn
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  4. Chun Woo Nam
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  5. Hyun Bong Park
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  6. Cheol Young Kim
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  7. Hyun Ok Yang
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Correspondence to Hyun Ok Yang.

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Choi, E.J., Kwon, H.C., Sohn, Y.C. et al. Four flavonoids from Echinosophora koreensis and their effects on alcohol metabolizing enzymes. Arch. Pharm. Res. 32, 851–855 (2009). https://doi.org/10.1007/s12272-009-1606-2

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  • DOI: https://doi.org/10.1007/s12272-009-1606-2

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