Abstract
Antifibrotic effect of twelve diterpenes (1–12) from the 90% methanolic fraction of Biota orientalis leaves was evaluated employing HSC-T6 cells by assessing cell proliferation and morphological change. Among these diterpenes, totarol (8) and isopimara-8(14),15-dien-19-oic acid (9) dramatically reduced cell proliferation in dose-and time-dependent manner. Furthermore, treatment with these compounds resulted in the different pattern of morphological changes of HSC-T6 cells. Taken together, antiproliferative activity of diterpenes from B. orientalis might suggest therapeutic potentials against liver fibrosis.
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Mi Kyeong Lee and Hyekyung Yang have contributed equally to this work.
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Lee, M.K., Yang, H., Yoon, J.S. et al. Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells. Arch. Pharm. Res. 31, 866–871 (2008). https://doi.org/10.1007/s12272-001-1239-9
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DOI: https://doi.org/10.1007/s12272-001-1239-9