Abstract
Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-β-D-galactoside (3), and quercetin 3-O-β-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC50 values of 72.7±6.2 and 117.2±10.5 μM, respectively. Silybin as a positive control showed an EC50 value of 82.4±4.1 μM.
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An, RB., Sohn, DH., Jeong, GS. et al. In Vitro hepatoprotective compounds from Suaeda glauca . Arch. Pharm. Res. 31, 594–597 (2008). https://doi.org/10.1007/s12272-001-1198-1
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DOI: https://doi.org/10.1007/s12272-001-1198-1