Abstract
Four crystal modifications of acyclovir were isolated by recrystallization and characterized by powder X-ray diffractometry, differential scanning calorimetry, and thermogravimetric analysis. It was confirmed that Form 3 is a hydrate and Form 4 is an acetic acid solvate. The dissolution patterns of three crystal forms of acyclovir were studied in water at 37±0.5°C, 90 rpm for 120 minutes. The amount dissolved at 120 minutes was highest for Form 1, followed by Form 2 and Form 3. After storage of 25 hours at 0% RH (silica gel, 20°C) Form 3 was transformed to Form 2.
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Sohn, Y.T., Kim, S.H. Polymorphism and pseudopolymorphism of acyclovir. Arch. Pharm. Res. 31, 231–234 (2008). https://doi.org/10.1007/s12272-001-1146-x
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DOI: https://doi.org/10.1007/s12272-001-1146-x