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Eosinophil Recovery Time Is Associated with Clinical Outcomes in Patients with Type A Acute Aortic Dissection: a Retrospective Cohort Study

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Abstract

Type A acute aortic dissection (TA-AAD) patients are prone to life-threatening complications and death. This study aimed to analyze the association between eosinophil (EOS) recovery and clinical outcomes in TA-AAD. A total of 274 patients with TA-AAD were eligible for inclusion, and 54 patients died within 1 month. The patients with poor clinical outcomes showed significantly lower EOS count within 8 days after surgery. The time-dependent ROC analysis showed that EOS recovery days predicted 1-month death with an AUC of 0.886 and a cutoff of 6 days. EOS recovery within 6 days was associated with a lower incidence of postoperative infection, a poorer prognosis, and a lower risk of 1-month and 6-month mortality than those requiring more recovery days. Collectively, postoperative early recovery of EOS predicted lower mortality and better prognosis and may be applied as an effective, rapid, and simple tool for the risk stratification and prognostic prediction of patients with TA-AAD.

Clinical trial registration number: NCT05409677.

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Funding

This work was supported by the Innovation Capability Strong Foundation Plan of Xi’an City (Medical Research Project, 21YXYJ0037), the Youth Science and Technology Rising Star Project of Shaanxi Province (2020KJXX-036), and the High-end Foreign Expert Introduction Program of National Science and Technology (G2022040014L).

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Author notes

  1. Xue Wang, Yanli Zhu, and Xiaojuan Ma contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an, China

    Xue Wang, Yang Yan & Chao Deng

  2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi’an, China

    Yanli Zhu, Xiaojuan Ma, Yanqing Liu, Shaofei Zhang & Yang Yang

  3. Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No.3 Hospital, The Affiliated Hospital of Northwest University, Northwest University, 10 Fengcheng Three Road, Xi’an, China

    Xiaojuan Ma

  4. Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, Shanghai, China

    Jun Ren

  5. Department of Emergency Medicine, Shaanxi Provincial People’s Hospital, 256 Youyi West Road, Xi’an, Shaanxi, China

    Heng Gao

  6. Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, Xi’an, China

    Ying Chen

Authors
  1. Xue Wang
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Correspondence to Yang Yang or Chao Deng.

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Wang, X., Zhu, Y., Ma, X. et al. Eosinophil Recovery Time Is Associated with Clinical Outcomes in Patients with Type A Acute Aortic Dissection: a Retrospective Cohort Study. J. of Cardiovasc. Trans. Res. (2024). https://doi.org/10.1007/s12265-023-10468-5

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