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Peripheral Blood RNAs and Left Ventricular Dysfunction after Myocardial Infarction: Towards Translation into Clinical Practice

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Abstract

The treatment and early outcome of patients with acute myocardial infarction (MI) have dramatically improved the past decades, but the incidence of left ventricular (LV) dysfunction post-MI remains high. Peripheral blood RNAs reflect pathophysiological changes during acute MI and the inflammatory process. Therefore, these RNAs are promising new markers to molecularly phenotype patients and improve the early identification of patients at risk of subsequent LV dysfunction. We here discuss the coding and long non-coding RNAs that can be measured in peripheral blood of patients with acute MI and list the advantages and limitations for implementation in clinical practice. Although some studies provide preliminary evidence of their diagnostic and prognostic potential, the use of these makers has not yet been implemented in clinical practice. The added value of RNAs to improve treatment and outcome remains to be determined in larger clinical studies. International consortia are now catalyzing renewed efforts to investigate novel RNAs that may improve post-MI outcome in a precision-medicine approach.

Peripheral blood RNAs reflect the inflammatory changes in acute MI. A number of studies provide preliminary evidence of their prognostic potential, although the use of these makers has not yet been assessed in clinical practice.

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Funding

This study was funded by Research Foundation Flanders, a score grant from the University of Leuven (PF10/014) and the Frans Van de Werf Fund for Clinical Cardiovascular Research.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, University Hospitals Leuven, Herestraat 49, B-3000, Leuven, Belgium

    Maarten Vanhaverbeke, Stefan Janssens & Peter R. Sinnaeve

  2. Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium

    Denise Veltman, Stefan Janssens & Peter R. Sinnaeve

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  1. Maarten Vanhaverbeke
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  2. Denise Veltman
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Correspondence to Maarten Vanhaverbeke.

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SJ is holder of a named chair at KU Leuven, financed by AstraZeneca. MVH is Belgian management committee substitute of the EU-CostAction CardioRNA CA17129. DV and PRS declare they have no conflict of interest.

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Vanhaverbeke, M., Veltman, D., Janssens, S. et al. Peripheral Blood RNAs and Left Ventricular Dysfunction after Myocardial Infarction: Towards Translation into Clinical Practice. J. of Cardiovasc. Trans. Res. 14, 213–221 (2021). https://doi.org/10.1007/s12265-020-10048-x

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