Abstract
In this study, we verify the association between the rs1333049 single nucleotide polymorphism (9p21.3) within CDKN2A-CDKN2B and coronary artery disease (CAD) in an Italian population. We replicated rs1333049_G allele association with a significantly reduced risk of CAD (OR = 0.816; 95% confidence interval [0.705–0.945]; p = 0.0065) in 711 CAD patients and 755 normal healthy individuals. This effect is maintained even stratifying patients by gender and by risk factors. A significant association was found with age of CAD onset. Interestingly, we found a protective trend of association between the rs1333049_G allele and peripheral artery disease, a progressive atherosclerotic condition in which plaque builds up in the arteries that carry blood to the head, organs, and limbs (OR = 0.724; 95% CI [0.520–1.007]; p = 0.054). No genotype-phenotype association was found with more severe CAD clinical parameters. If certain genetic factors predispose individuals to adverse outcomes, the knowledge of a patient’s genotype may influence clinical management.
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12 July 2017
An erratum to this article has been published.
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This study was approved by the Ethics Committee of the Medical University of Naples.
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The authors declare that they have no conflicts of interest.
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Associate Editor Paul J. R. Barton oversaw the review of this article
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Pignataro, P., Pezone, L., Di Gioia, G. et al. Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population. J. of Cardiovasc. Trans. Res. 10, 455–458 (2017). https://doi.org/10.1007/s12265-017-9758-9
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DOI: https://doi.org/10.1007/s12265-017-9758-9