References
Hikosaka O. The habenula: from stress evasion to value-based decision-making. Nat Rev Neurosci 2010, 11: 503–513.
Benabid AL, Jeaugey L. Cells of the rat lateral habenula respond to high-threshold somatosensory inputs. Neurosci Lett 1989, 96: 289–294.
Khalilzadeh E, Saiah GV. The possible mechanisms of analgesia produced by microinjection of morphine into the lateral habenula in the acute model of trigeminal pain in rats. Res Pharm Sci 2017, 12: 241–248.
Shelton L, Becerra L, Borsook D. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol 2012, 96: 208–219.
Cui WQ, Zhang WW, Chen T, Li Q, Xu F, Mao-Ying QL. Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta Neuropathol Commun 2020, 8: 44.
Hu TT, Wang RR, Tang YY, Wu YX, Yu J, Hou WW, et al. TLR4 deficiency abrogated widespread tactile allodynia, but not widespread thermal hyperalgesia and trigeminal neuropathic pain after partial infraorbital nerve transection. Pain 2018, 159: 273–283.
Lee DJ, Lozano CS, Dallapiazza RF, Lozano AM. Current and future directions of deep brain stimulation for neurological and psychiatric disorders. J Neurosurg 2019, 131: 333–342.
Fuchs P, Cox VC. Habenula lesions attenuate lateral hypothalamic analgesia in the formalin test. Neuroreport 1993, 4: 121–124.
Quina LA, Walker A, Morton G, Han V, Turner EE. GAD2 expression defines a class of excitatory lateral habenula neurons in mice that project to the raphe and pontine tegmentum. eNeuro 2020, 7: ENEURO.0527–19.2020.
Edwards RR, Dworkin RH, Sullivan MD, Turk DC, Wasan AD. The role of psychosocial processes in the development and maintenance of chronic pain. J Pain 2016, 17: T70–T92.
Ghasemi Z, Naderi N, Shojaei A, Raoufy MR, Ahmadirad N, Barkley V, et al. The inhibitory effect of different patterns of low frequency stimulation on neuronal firing following epileptiform activity in rat hippocampal slices. Brain Res 2019, 1706: 184–195.
Ruan Y, Xu C, Lan J, Nao J, Zhang S, Fan F, et al. Low-frequency stimulation at the subiculum is anti-convulsant and anti-drug-resistant in a mouse model of lamotrigine-resistant temporal lobe epilepsy. Neurosci Bull 2020, 36: 654–658.
Wilcox KS, Gutnick MJ, Christoph GR. Electrophysiological properties of neurons in the lateral habenula nucleus: an in vitro study. J Neurophysiol 1988, 59: 212–225.
Li B, Piriz J, Mirrione M, Chung C, Proulx CD, Schulz D, et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature 2011, 470: 535–539.
Dandekar MP, Fenoy AJ, Carvalho AF, Soares JC, Quevedo J. Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications. Mol Psychiatry 2018, 23: 1094–1112.
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This work was supported by grants from National Natural Science Foundation of China (81872843, 81673404, and 81821091).
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Du, Y., Wu, YX., Guo, F. et al. Lateral Habenula Serves as a Potential Therapeutic Target for Neuropathic Pain. Neurosci. Bull. 37, 1339–1344 (2021). https://doi.org/10.1007/s12264-021-00728-2
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DOI: https://doi.org/10.1007/s12264-021-00728-2