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Synthetic regulatory tools for microbial engineering

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Abstract

Microbial engineering requires accurate information about cellular metabolic networks and a set of molecular tools that can be predictably applied to the efficient redesign of such networks. Recent advances in the field of metabolic engineering and synthetic biology, particularly the development of molecular tools for synthetic regulation in the static and dynamic control of gene expression, have increased our ability to efficiently balance the expression of genes in various biological systems. It would accelerate the creation of synthetic pathways and genetic programs capable of adapting to environmental changes in real time to perform the programmed cellular behavior. In this paper, we review current developments in the field of synthetic regulatory tools for static and dynamic control of microbial gene expression.

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Authors and Affiliations

  1. Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 790-784, Korea

    Sang Woo Seo & Gyoo Yeol Jung

  2. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 790-784, Korea

    Seong Cheol Kim & Gyoo Yeol Jung

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  1. Sang Woo Seo
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Seo, S.W., Kim, S.C. & Jung, G.Y. Synthetic regulatory tools for microbial engineering. Biotechnol Bioproc E 17, 1–7 (2012). https://doi.org/10.1007/s12257-011-0563-z

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