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Advantages in Prognosis of Adult Patients with Ewing Sarcoma: 11-years Experiences and Current Treatment Management

  • Original Article
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Pathology & Oncology Research

Abstract

Ewing sarcoma (ES) is an exceptionally rare tumor in adults. Data regarding outcomes of adult patients with ES and experiences with age-adapted therapeutic strategies are very limited. The aim of this study was to evaluate prognostic factors and clinical outcome in a cohort of adult patients treated according to pediatric protocols in the Czech Republic. The records of 58 adult ES patients diagnosed between 2002 and 2013 were reviewed and factors relevant to prognosis and survival were analyzed. The median age of study cohort was 29 years (range, 18–59). The most frequent location was axial (36.2%), followed by involvement of extraskeletal tissues (34.5%) and bones of the extremities (29.3%). Twenty-eight (48.3%) patients had metastatic disease. In cases with localized ES, the 5-year overall survival (OS) was 76.5%. Using the log-rank test, the presence of metastasis at diagnosis, local treatment without surgery and a failure to achieve complete remission were associated with significantly shorter survival. In a multivariate Cox proportional hazard analysis, the achievement of complete remission was an independent predictor of patients’s survival time. Outcomes of adults with localized ES treated according to multimodal pediatric protocols are similar to children. The achievement of complete remission is an independent predictor of survival time in ES patients. Severe hematological toxicity is foreseeable and manageable. Prognosis of patients with metastases or progression remains dismal.

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Funding

This study was supported by the Ministry of Health, Czech Republic: MH CZ - DRO (MMCI, 00209805).

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Authors and Affiliations

  1. Clinic of Comprehensive Cancer Care of Masaryk Memorial Cancer Institute, Brno, Czech Republic

    Dagmar Adamkova Krakorova, Stepan Tucek & Igor Kiss

  2. Second Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    Katerina Kubackova & Jana Prausova

  3. Department of Oncology, Motol University Hospital, Prague, Czech Republic

    Katerina Kubackova & Jana Prausova

  4. Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University, Brno, Czech Republic

    Ladislav Dusek

  5. First Orthopedic Department, St. Anne’s University Hospital, Brno, Czech Republic

    Tomas Tomas & Pavel Janicek

  6. First Department of Pathological Anatomy, St. Anne’s University Hospital, Pekarska 53, 656 91, Brno, Czech Republic

    Iva Zambo

Authors
  1. Dagmar Adamkova Krakorova
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  2. Katerina Kubackova
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  3. Ladislav Dusek
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  4. Tomas Tomas
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  7. Jana Prausova
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  8. Igor Kiss
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  9. Iva Zambo
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Corresponding author

Correspondence to Iva Zambo.

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The authors declare no conflicts of interest.

Ethical Approval

All procedure performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Krakorova, D.A., Kubackova, K., Dusek, L. et al. Advantages in Prognosis of Adult Patients with Ewing Sarcoma: 11-years Experiences and Current Treatment Management. Pathol. Oncol. Res. 24, 623–630 (2018). https://doi.org/10.1007/s12253-017-0291-6

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  • DOI: https://doi.org/10.1007/s12253-017-0291-6

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