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Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer

  • Original Article
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Pathology & Oncology Research

Abstract

Current literature gives evidence of an indisputable role adiponectin plays in adipose tissue metabolism and obesity-related diseases. Moreover, latest research efforts focus on linking genetic markers of this adipocytokine’s gene (ADIPOQ) with cancer. Aim of this study was to determine the genotype distribution of single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ and an attempt to identify the impact this polymorphism exerts on endometrial cancer risk in obese females. The test group comprised 90 women treated surgically for endometrial cancer between 2000 and 2012 in the Department of Surgical & Endoscopic Gynecology and Gynecologic Oncology, Polish Mothers’ Memorial Hospital - Research Institute, Lodz, Poland. 90 individuals treated in the parallel period for uterine fibroids constituted the control group. Patients within both groups were stratified according to BMI into: lean, overweight and obese subjects. Statistical analysis was performed between two major groups and, furthermore, within the abovementioned subgroups. The analysis revealed that allele G of the investigated polymorphism in obese women with endometrial cancer is significantly more frequent, and allele T is significantly less frequent than in lean controls. However, no significant correlation was observed between the polymorphism and endometrial cancer in lean and overweight females. Single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ may be considered to be a risk factor of endometrial cancer. Further research on SNP in EC is warranted to obtain more conclusive outcomes.

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Conflict of Interest

We declare that we have no conflict of interest.

Authors' Contribution

Jan Bieńkiewicz: protocol and project development, data collection and management, manuscript writing and editing.

Beata Smolarz: genetical assays and data analysis.

Andrzej Malinowski: protocol and project development.

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Authors and Affiliations

  1. Department of Surgical & Endoscopic Gynecology and Gynecologic Oncology, Polish Mothers’ Memorial Hospital-Research Institute, Lodz, Poland

    Jan Bieńkiewicz & Andrzej Malinowski

  2. Laboratory of Molecular Genetics, Department of Pathology, Polish Mothers’ Memorial Hospital-Research Institute, Lodz, Poland

    Beata Smolarz

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  1. Jan Bieńkiewicz
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Correspondence to Jan Bieńkiewicz.

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Bieńkiewicz, J., Smolarz, B. & Malinowski, A. Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer. Pathol. Oncol. Res. 22, 135–138 (2016). https://doi.org/10.1007/s12253-015-9985-9

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  • DOI: https://doi.org/10.1007/s12253-015-9985-9

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