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The Effect of LMWH (Nadroparin) on Tumor Progression

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Pathology & Oncology Research

Abstract

Recent clinical studies on patients with malignancies, who were treated with UHF and LMWHs raised the possibility, that these agents may possess an inhibitory effect on tumor progression. Further studies supported that this effect is independent from the anticoagulant and antithrombotic action. In this retrospective study oncological patients with an increased risk for thromboembolism were choosen, who received prophylactic treatment with an LMWH (nadroparin) at least for 6 months. Comparing with the control group, in some subgroups (T3 and T4, as well as M1) the LMWH-treated patients showed a significantly increased survival.

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References

  1. von Delius S, Ayvaz M, Wagenpfeil S et al (2007) Effect of low-molecular-weight heparin on survival in patients with advanced pancreatic adenocarcinoma. Thromb Haemost 98:434–439

    Google Scholar 

  2. Lazo-Lagner A, Goss GD, Spaans JN et al (2007) The effect of low-molecular-weight heparin on cancer survival. A systematic review and meta-analysis of randomized trials. J Thrombosis Haemostasis 5:729–737

    Article  Google Scholar 

  3. Kakkar AK (2005) Low-molecular-weight heparin and survival in patients with malignant disease. Cancer Control 12:22–30

    PubMed  Google Scholar 

  4. Akl EA, VanDoormaal FF, Barba M et al (2008) Parenteral anticoagulation may prolong the survival of patients with limited small cell lung cancer: a Cochrane systematic review. J Exp Clin Cancer Res 27:4

    Article  PubMed  Google Scholar 

  5. Kakkar AK, Levine MN, Kadziola Z (2004) Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 22:1944–1948

    Article  CAS  PubMed  Google Scholar 

  6. Tóvári J, Bereczky B, Gilly R et al (2004) Effect of heparin treatment on the metastatization of melanoma in a preclinical model (in Hungarian). Magy Onkol 48:235–241

    PubMed  Google Scholar 

  7. De Lorenzo F, Dotsenko O, Scully MF et al (2006) The Role of Anticoagulation in Cancer Patients: Facts and Figures. Anti-Cancer Agents Med Chem 6:579–587

    Article  Google Scholar 

  8. Klerk CPW, Smorenburg SM, Otten HM et al (2005) The Effect of Low Molecular Weight Heparin on Survival in Patients With Advanced Malignancy. J Clin Oncol 23:2130–2135

    Article  CAS  PubMed  Google Scholar 

  9. Li JP (2008) Heparin, heparan sulfate and heparanase in cancer: remedy for metastasis? Anti-Cancer Agents Med Chem 8:64–76

    Article  Google Scholar 

  10. Falanga A, Marchetti M (2007) Heparin in tumor progression and metastatic dissemination. Semin Thromb Haemost 33:688–694

    Article  CAS  Google Scholar 

  11. Castelli R, Porro F, Tarsia P (2004) The heparins and cancer: review of clinical trials and biological properties. Vasc Med 9:205–213

    Article  PubMed  Google Scholar 

  12. Vlodavsky I, Ilan N, Nadir Y et al (2007) Heparanase, heparin and the coagulation system in cancer progression. Thromb Res 120:112–120

    Article  Google Scholar 

  13. Casu B, Vlodavsky I, Sanderson RD (2009) Pathophysiol Haemost Thromb 2007-08: 36, 195–203, doi: 10.1159/000175157

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Correspondence to Zsuzsanna Nagy.

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Nagy, Z., Turcsik, V. & Blaskó, G. The Effect of LMWH (Nadroparin) on Tumor Progression. Pathol. Oncol. Res. 15, 689–692 (2009). https://doi.org/10.1007/s12253-009-9204-7

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  • DOI: https://doi.org/10.1007/s12253-009-9204-7

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