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Hairy Cell Leukemia-Related Disorders Consistently Show Low CD27 Expression

  • Original Paper
  • Published:
Pathology & Oncology Research

Abstract

In Japan, typical hairy cell leukemia (HCL) is rare, and HCL-Japanese variant (HCL-JV) is more common. Hairy B-cell lymphoproliferative disorder (HBLD) is another unusual disorder of polyclonal B-lymphocytosis of hairy cell appearance. In the present study, we analyzed the clinical features of 3 patients with HCL, 3 with HCL-JV, and 3 with HBLD. All HBLD patients had the DRB1*04 allele. As compared with other B-cell lymphoproliferative disorders, CD27 expression on B cells was significantly lower in all patients, ranging from 0.3% to 23.4%. Our results suggest that low CD27 expression may be a distinct feature of these HCL-related disorders.

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Authors and Affiliations

  1. Department of Medicine and Clinical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan

    Yoko Hashimoto, Norifumi Tsukamoto, Hirotaka Nakahashi, Akihiko Yokohama, Takayuki Saitoh, Takafumi Matsushima & Yoshihisa Nojima

  2. School of Health Science, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan

    Hiroshi Handa & Hirokazu Murakami

  3. Blood Transfusion Service, University Hospital, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Masamitsu Karasawa

Authors
  1. Yoko Hashimoto
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  2. Norifumi Tsukamoto
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  3. Hirotaka Nakahashi
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  4. Akihiko Yokohama
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  5. Takayuki Saitoh
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  6. Hiroshi Handa
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  7. Takafumi Matsushima
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  8. Hirokazu Murakami
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  9. Yoshihisa Nojima
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  10. Masamitsu Karasawa
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Corresponding author

Correspondence to Masamitsu Karasawa.

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Hashimoto, Y., Tsukamoto, N., Nakahashi, H. et al. Hairy Cell Leukemia-Related Disorders Consistently Show Low CD27 Expression. Pathol. Oncol. Res. 15, 615–621 (2009). https://doi.org/10.1007/s12253-009-9161-1

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  • DOI: https://doi.org/10.1007/s12253-009-9161-1

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