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Differential Cytokine Pattern in the Exhaled Breath of Patients with Lung Cancer

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  • Published:
Pathology & Oncology Research

Abstract

Tumour cells may alter the protein pattern of biological samples resulting in specific differences that may aid diagnosis and treatment. In this pilot study we tested the cytokine pattern of exhaled breath condensate of patients with lung cancer. Breath condensates collected from 50 smoking patients with lung cancer and 25 smokers without clinical or radiological sign of a pulmonary tumour but having co-morbidities with similar severity as those with lung cancer were pooled for antibody microarray analysis testing 120 cytokines in parallel. Every cytokine on the array gave a signal in both groups. Nine cytokines including eotaxin, FGFs, IL-10 and MIP-3 were present with more than two-fold difference between the two groups. Large number of cytokines is present in the exhaled breath. Further analysis of specific differences associated with lung cancer may have clinical importance.

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Abbreviations

EBC:

exhaled breath condensate

FVC:

forced vital capacity

FEV1:

forced expiratory volume in 1 s

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Acknowledgements

We are thankful to Ms. M. Kenéz for the collection of exhaled breath condensate samples and to Dr. Zoltán Prohászka and László Cervenák (Semmelweis University, III. Dept. of Internal Medicine) for critical comments and help with chemiluminescent imaging. This study was supported by the Hungarian National Scientific Research Fund (OTKA 68808).

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Authors and Affiliations

  1. Department of Pathophysiology, National Korányi Institute for TB and Pulmonology, Budapest, Hungary

    Tamás Kullmann, Imre Barta & Balázs Antus

  2. Department of Pulmonology, National Korányi Institute for TB and Pulmonology, Budapest, Hungary

    Eszter Csiszér & Balázs Antus

  3. Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Üllői street 78/a, Budapest, 1082, Hungary

    Ildikó Horváth

Authors
  1. Tamás Kullmann
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  2. Imre Barta
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  3. Eszter Csiszér
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  4. Balázs Antus
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  5. Ildikó Horváth
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Corresponding author

Correspondence to Ildikó Horváth.

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Kullmann, T., Barta, I., Csiszér, E. et al. Differential Cytokine Pattern in the Exhaled Breath of Patients with Lung Cancer. Pathol. Oncol. Res. 14, 481–483 (2008). https://doi.org/10.1007/s12253-008-9046-8

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  • DOI: https://doi.org/10.1007/s12253-008-9046-8

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