Abstract
The X protein (HBx) of Human hepatitis B virus (HBV) acts as an indirect transcriptional transactivator to regulate the expression of many viral and cellular genes, as well as playing a critical role in pathogenesis and the development of Hepatocellular carcinoma (HCC). Here we described the biological effects of HBx in association with four cellular factors, including inflammatory factors (COX-2 and iNOS), oncoprotein (Ras), and a newly identified tumor suppressor (YueF). The characteristics of these effectors, which might be associated with hepatocellular carcinoma, are also discussed.
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Foundation items: the Major State Basic Research Development Program of China (“973” project No. 2005CB5 22901 and No. 2005CB522905); The National Natural Science Foundation of China (No. 30470087 and No. 30730001), The Department of Science Technology of Hubei Province (No. 2005S2354), and Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) to J. Wu.
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Wang, Sq., Wu, Jg. Biological effects of HBV X protein on hepatocellular carcinogenesis in association with cellular factors. Virol. Sin. 23, 146–151 (2008). https://doi.org/10.1007/s12250-008-2952-9
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DOI: https://doi.org/10.1007/s12250-008-2952-9