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Fusidic Acid Microemulsion Based on a Pseudoternary Phase Diagram: Development, Characterization, and Evaluation

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Abstract

Purpose

Microemulsions (MEs) are homogeneous, optically clear and thermodynamically stable systems intended to increase the bioavaibility, solubility, and entrapment of drugs. In this study, a new system of oil-in-water MEs was formulated with Fusidic acid as a drug. MEs were composed of Isopropyl myristate, non-ionic surfactants tween 80, 1-propanol and water.

Methods

The optimum weight ratios of components and MEs areas were determined by pseudoternary phase diagram. The prepared microemulsions were evaluated regarding their stability, pH, refractive index, conductivity, viscosity, particle size, zeta potential, surface tension and partition coefficient.

Results

These parameters suggested that the optimized MEs were stable and optically clear.

Conclusion

This study reveals that the product can be used for ocular treatment.

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Authors and Affiliations

  1. Faculty of Mechanical and Process Engineering, University of Science and Technology Houari Boumediene, B.P. 32, 16111, El Alia, Bab Ezzouar, Algiers, Algeria

    Lynda Lamoudi, Soraya Akretche & Kamel Daoud

  2. Faculty of Industrial Chemistry, University of Saad, Dahlab Blida 1, Route de Soumaa BP 270, 09000, Blida, Algeria

    Abdelkader Hadjsadok

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  1. Lynda Lamoudi
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Correspondence to Lynda Lamoudi.

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Lamoudi, L., Akretche, S., Hadjsadok, A. et al. Fusidic Acid Microemulsion Based on a Pseudoternary Phase Diagram: Development, Characterization, and Evaluation. J Pharm Innov 18, 621–628 (2023). https://doi.org/10.1007/s12247-022-09668-4

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