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Nanocrystals: Characterization Overview, Applications in Drug Delivery, and Their Toxicity Concerns

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Abstract

Nanocrystals (NCs) are the class of solid dosage forms which utilizes the concept of nanoscience together with crystal nature of drug to achieve advantages in terms of solubility, dissolution, and physicochemical properties. Comparing with other solid dosage forms, NC often comes with so many challenges in terms of physical stability as well as chemical stability during the manufacturing process and storage. Therefore, physicochemical properties of nanocrystals, toxic effect on the human body, and application in drug delivery through the various routes of administration are critical step formulation of NCs. There are various techniques involved to ensure solid state uniformity in the NCs and its impact on therapeutic performance. This review article emphasizes on various solid-state characterization techniques that are used to evaluate NCs, their toxicity, and pharmaceutical application. Further, NC-based marketed formulation is also discussed in this review.

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Authors and Affiliations

  1. Department of Pharmaceutics, Nibha Institute of Pharmaceutical Sciences, Nalanda, Rajgir, Bihar, 803116, India

    Mohammed Asadullah Jahangir

  2. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Syed Sarim Imam & Sultan Alshehri

  3. Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, 110062, India

    Abdul Muheem

  4. Center for Nanomedicine, Department of Pharmaceutics, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Telangana, 500088, India

    Ananda Chettupalli

  5. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Fahad A. Al-Abbasi, Muhammad Shahid Nadeem & Imran Kazmi

  6. Glocal School of Pharmacy , Glocal University , Saharanpur, Uttar Pradesh, 247121, India

    Imran Kazmi & Muhammad Afzal

  7. Department of Pharmacology College of Pharmacy , Jouf Uiversity , Sakaka, 72388, Saudi Arabia

    Muhammad Afzal

  8. College of Pharmacy, Almaarefa University, Riyadh, Saudi Arabia

    Sultan Alshehri

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  1. Mohammed Asadullah Jahangir
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Jahangir, M.A., Imam, S.S., Muheem, A. et al. Nanocrystals: Characterization Overview, Applications in Drug Delivery, and Their Toxicity Concerns. J Pharm Innov 17, 237–248 (2022). https://doi.org/10.1007/s12247-020-09499-1

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