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Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS)

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Abstract

Cutaneous T cell lymphoma is a heterogeneous group of lymphoproliferative disorders with different clinical behavior and prognosis in which malignant T cells accumulate in the skin. In the relapsed/refractory stage, treatment strategy varies depending on clinical perspective. We retrospectively evaluated advanced stage relapse or refractory mycosis fungoides and Sezary syndrome patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our hospital. The overall response rate was 25%, while the disease progressed and relapsed after transplant in 38% of patients. Allo-HSCT may be a reasonable treatment option in the relapsed/refractory stage.

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Authors and Affiliations

  1. BMT Unit, Department of Hematology, Cebeci Hospital, School of Medicine, Ankara University, Dikimevi, 06590, Ankara, Turkey

    Erden Atilla, Pinar Ataca Atilla, Sinem Civriz Bozdag, Meltem Kurt Yuksel, Selami Kocak Toprak, Pervin Topcuoglu, Hatice Sanli, Gunhan Gurman & Muhit Ozcan

  2. Department of Dermatology, School of Medicine, Ankara University, Ankara, Turkey

    Bengu Nisa Akay & Hatice Sanli

Authors
  1. Erden Atilla
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  2. Pinar Ataca Atilla
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  3. Sinem Civriz Bozdag
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  4. Meltem Kurt Yuksel
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  5. Selami Kocak Toprak
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  6. Pervin Topcuoglu
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  7. Bengu Nisa Akay
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  8. Hatice Sanli
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  9. Gunhan Gurman
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  10. Muhit Ozcan
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Correspondence to Erden Atilla.

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Atilla, E., Atilla, P.A., Bozdag, S.C. et al. Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS). Int J Hematol 106, 426–430 (2017). https://doi.org/10.1007/s12185-017-2245-x

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  • DOI: https://doi.org/10.1007/s12185-017-2245-x

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