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A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case

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Abstract

Background

Granular Cell Odontogenic Fibroma (GCOF) is a rare odontogenic neoplasm reported over time with different names. The purpose of this study is to review all available data on the GCOF in the scientific literature, with a summary of all reported cases and a report of a new case.

Methods

This review was conducted following the PRISMA guidelines. An electronic search was performed up to November 2022.

Results

Thirty-nine studies reporting fifty-three cases were included. GCOF is a rare neoplasm among the odontogenic tumors, with a higher prevalence in women of the middle-aged and white population. This lesion occurs mostly on the posterior region of the mandible. Furthermore, based on clinical, radiographic, and histopathologic features, conservative treatment was the most reported choice with recurrence reported in two cases.

Conclusion

GCOF remains controversial due to the still unsolved histogenesis.

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Data Availability

The manuscript has data included as electronic supplementary material.

Code Availability

The manuscript has data included as electronic supplementary material.

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Acknowledgements

The authors declare that this study received financial support and that this manuscript, or any part, has not been submitted or published and will not be submitted elsewhere for publication while being considered by the Head and Neck Journal.

Funding

This work was supported by grants from the Research Support Foundation of the State of Pernambuco, Brazil (FACEPE, Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco) and from the Coordination for the Improvement of Higher Education Personnel (CAPES, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior).

Author information

Authors and Affiliations

  1. University of Pernambuco (UPE), School of Dentistry, Recife, PE, Brazil

    Raisa Jordana Geraldine Severino Lazo, Allan Vinícius Martins-de-Barros, Jéssica da Silva Cunha, Rómulo Augusto de Paiva Macedo, Belmiro Cavalcanti do Egito Vasconcelos & Marianne de Vasconcelos Carvalho

  2. Oswaldo Cruz University Hospital (UPE), Integrated Anatomic Pathology Center, Recife, PE, Brazil

    Raisa Jordana Geraldine Severino Lazo, Allan Vinícius Martins-de-Barros, Jéssica da Silva Cunha, Mariana de Albuquerque Borges & Marianne de Vasconcelos Carvalho

  3. Department of Oral and Maxillofacial Surgery, Oswaldo Cruz University Hospital (UPE, Recife, PE, Brazil

    Rómulo Augusto de Paiva Macedo & Belmiro Cavalcanti do Egito Vasconcelos

  4. Department of Oral and Maxillofacial Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL, USA

    Mohammed N. Islam

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  1. Raisa Jordana Geraldine Severino Lazo
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Contributions

RJGSL, AVMB, and MVC contributed to the study conception and design. Material preparation, search strategy, and data selection were performed by RJGSL, AVMB BCEV, and RAPM. Clinicopathologic review according to WHO criteria and data extraction were performed by RJGSL, JSC, and MAB. Artwork and graphic figures were performed by RJGSL and AVMB. The first draft of the manuscript was written by RJGSL and AVMB; writing review and editing by MNI and MVC. All authors commented on previous versions of the manuscript.

Corresponding author

Correspondence to Belmiro Cavalcanti do Egito Vasconcelos.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from the patient included in this article. No identifying information is included in the case report, and the study meets the exemption criteria for the Institutional Review Board of the University of Pernambuco.

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Severino Lazo, R.J.G., Martins-de-Barros, A.V., da Silva Cunha, J. et al. A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case. Head and Neck Pathol 17, 793–802 (2023). https://doi.org/10.1007/s12105-023-01553-x

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