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Sebaceous Lymphadenoma: Radiology–Pathology Correlation

  • Sine qua non Radiology-Pathology
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Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Sebaceous lymphadenoma is a rare salivary gland neoplasm most commonly occurring in the sixth to eighth decades of life. Cross sectional imaging typically demonstrates a multicystic expansile mass, most commonly occurring in the parotid gland, where the radiographic differential diagnosis would include Warthin tumor in this location and age group. Ultimately, the diagnosis is confirmed with the histopathologic findings of tubuloglandular epithelial profiles with sebaceous differentiation and cystic change set within a dense, benign lymphocytic infiltrate. These features are exemplified in this sine qua non radiology–pathology correlation article.

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References

  1. Seethala RR, Thompson LD, Gnepp DR, et al. Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2012;25(1):26–35.

    Article  Google Scholar 

  2. Viswanathan K, Maleki Z, Pantanowitz L, Cantley R, Faquin WC (2020) Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi-institutional study. Diagn Cytopathol. doi: 10.1002/dc.24602

  3. Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer. 1984;53(10):2155–70.

    Article  CAS  Google Scholar 

  4. El-Naggar AK, Chan JK, Grandis JR, Slootweg PJ. WHO classification of head and neck tumours, 4th Edn. Lyon: IARC press; 2017. p. 190–1.

    Google Scholar 

  5. McGavran MH, Bauer WC, Ackerman LV. Sebaceous lymphadenoma of the parotid salivary gland. Cancer. 1960;13:1185–7.

    Article  CAS  Google Scholar 

  6. Rawson AJ, Horn RC Jr. Sebaceous glands and sebaceous gland-containing tumors of the parotid salivary gland; with a consideration of the histogenesis of papillary cystadenoma lymphomatosum. Surgery. 1950;27(1):93–101. illust.

    CAS  PubMed  Google Scholar 

  7. Pattnaik N, Parmar D, Rao BR, Rao ES. Sebaceous lymphadenoma of submandibular gland. J Indian Med Assoc. 2013;111(1):62–3.

    PubMed  Google Scholar 

  8. Weissferdt A, Kalhor N, Moran CA. Sebaceous lymphadenoma of the thymus: a clinicopathologic and immunohistochemical study of 2 cases. Hum Pathol. 2016;56:189–93.

    Article  CAS  Google Scholar 

  9. Rawlinson NJ, Almarzooqi S, Nicol K. Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report. Head Neck Pathol. 2010;4(2):144–7.

    Article  Google Scholar 

  10. Deysine M, Mann BF. Jr. Sebaceous lymphadenoma of the parotid gland: associated with a case of bilateral parotid gland tumors. Ann Surg. 1969;169(3):437–43.

    Article  CAS  Google Scholar 

  11. Assor D. Sebaceous lymphadenoma of the parotid gland. A case report. Am J Clin Pathol. 1970;53(1):100–3.

    Article  CAS  Google Scholar 

  12. Wasan SM. Sebaceous lymphadenoma of the parotid gland. Cancer. 1971;28(4):1019–22.

    Article  CAS  Google Scholar 

  13. Mayorga M, Fernandez N, Val-Bernal JF. Synchronous ipsilateral sebaceous lymphadenoma and acinic cell adenocarcinoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(5):593–6.

    Article  CAS  Google Scholar 

  14. Boyle JL, Meschter SC. Fine needle aspiration cytology of a sebaceous lymphadenoma: a case report. Acta Cytol. 2004;48(4):551–4.

    Article  Google Scholar 

  15. Maffini F, Fasani R, Petrella D, et al. Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007;27(3):147–50.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Zhang C, Gu T, Hu Y, et al. Reevaluation of salivary lymphadenoma. Arch Pathol Lab Med. 2020. https://doi.org/10.5858/arpa.2019-0702-OA.

    Article  PubMed  Google Scholar 

  17. Potenziani S, Applebaum D, Krishnan B, Gutierrez C, Diwan AH. Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome—a case report. J Cutan Pathol. 2017;44(1):79–82.

    Article  Google Scholar 

  18. Liu G, He J, Zhang C, Fu S, He Y. Lymphadenoma of the salivary gland: report of 10 cases. Oncol Lett. 2014;7(4):1097–101.

    Article  Google Scholar 

  19. Banich J, Reyes CV, Bier-Laning C. Sebaceous lymphadenoma identified by fine needle aspiration biopsy: a case report. Acta Cytol. 2007;51(2):211–3.

    Article  Google Scholar 

  20. Meza-Chavez L. Sebaceous glands in normal and neoplastic parotid glands; possible significance of sebaceous glands in respect to the origin of tumors of the salivary glands. Am J Pathol. 1949;25(4):627–45.

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Gnepp DR. My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol. 2012;6(1):101–10.

    Article  Google Scholar 

  22. Jazaerly T, Bandyopadhyay S, Almardini N, Husain M. Diagnosis of sebaceous lymphadenoma by fine needle aspiration in a patient with Cowden syndrome: case report and review of the literature. Cytojournal. 2014;11:25.

    Article  Google Scholar 

  23. Scheller EL, Pritchett CV, Shukla A, Pepper JP, Marentette LJ, McHugh JB. Synchronous ipsilateral sebaceous lymphadenoma and membranous basal cell adenoma of the parotid. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(4):e41–6.

    Article  Google Scholar 

  24. Auclair PL, Ellis GL, Gnepp DR. Other benign epithelial neoplasms. Philadelphia: WB Saunders; 1991.

    Google Scholar 

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Authors and Affiliations

  1. Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 30308, USA

    Melad N. Dababneh & Kelly R. Magliocca

  2. Department of Otolaryngology, Emory University, Atlanta, GA, USA

    Mihir R. Patel

  3. Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Mihir R. Patel & Kelly R. Magliocca

  4. Department of Pathology, Cleveland Clinic, Cleveland, OH, USA

    Christopher C. Griffith

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  1. Melad N. Dababneh
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  2. Christopher C. Griffith
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  3. Mihir R. Patel
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  4. Kelly R. Magliocca
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Correspondence to Kelly R. Magliocca.

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Dababneh, M.N., Griffith, C.C., Patel, M.R. et al. Sebaceous Lymphadenoma: Radiology–Pathology Correlation. Head and Neck Pathol 15, 593–598 (2021). https://doi.org/10.1007/s12105-020-01266-5

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  • DOI: https://doi.org/10.1007/s12105-020-01266-5

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