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Intraductal Carcinoma of Salivary Glands Harboring TRIM27-RET Fusion with Mixed Low Grade and Apocrine Types

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Abstract

Intraductal carcinomas (IDCs) of salivary gland are rare neoplasms. Here, we report a case of IDCs harboring TRIM27-RET fusion with mixed low grade and apocrine types. A 79-year-old male presented with slowly-growing left parotid mass for 2.5 years. Histologically, the tumor demonstrated two distinct morphologies; a classic intercalated duct and low grade apocrine component. The intercalated duct component was positive for S100, SOX10 and vimentin, and negative for DOG-1 and HER2. The apocrine component was positive for androgen receptor (AR) and focally positive for HER2. The tumor harbored a TRIM27-RET fusion by FISH, and was negative for ETV6 and PLAG1 rearrangements. This case is unusual in that it displays two true phenotypically distinct components, which has only rarely been reported. This is the first report of intraductal carcinoma with two true phenotypically distinct components composed of low-grade and apocrine types with RET rearrangement and TRIM27-RET fusion.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, L25, Cleveland, OH, 44195, USA

    Haiyan Lu & Deborah Chute

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Rondell P. Graham

  3. Department of Pathology, University of Pittsburgh, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA

    Raja Seethala

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  1. Haiyan Lu
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  2. Rondell P. Graham
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  3. Raja Seethala
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  4. Deborah Chute
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Correspondence to Haiyan Lu.

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Lu, H., Graham, R.P., Seethala, R. et al. Intraductal Carcinoma of Salivary Glands Harboring TRIM27-RET Fusion with Mixed Low Grade and Apocrine Types. Head and Neck Pathol 14, 239–245 (2020). https://doi.org/10.1007/s12105-018-0996-1

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