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Laryngotracheal Involvement in Systemic Light Chain Amyloidosis

  • Sine qua non Radiology-Pathology
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Abstract

Laryngotracheal amyloid deposition is an uncommon manifestation of systemic light chain amyloidosis. Diagnostic imaging, such as CT, is useful for suggesting the possibility of amyloidosis and delineating the extent of the lesions for surgical management; however, the diagnosis is confirmed with the histologic finding of amorphous eosinophilic material which stains positively for Congo red and may show apple green birefringence on polarization. These features are exemplified in this sine qua non radiology-pathology correlation article.

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Aknowledgements

We are grateful for support received from the University of Chicago Office of Faculty Affairs through the Faculty Initiatives Fund for our Head and Neck Radiology-Pathology Trainee Conference, during which this case was presented.

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Authors and Affiliations

  1. Department of Radiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA

    Daniel T. Ginat

  2. Department of Pathology, University of Chicago, Chicago, IL, USA

    Jefree Schulte & Nicole A. Cipriani

  3. Department of Surgery, Section of Otolaryngology, University of Chicago, Chicago, IL, USA

    Louis Portugal

Authors
  1. Daniel T. Ginat
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  2. Jefree Schulte
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  3. Louis Portugal
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  4. Nicole A. Cipriani
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Correspondence to Daniel T. Ginat.

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The authors declare that they have no competing interests.

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Ginat, D.T., Schulte, J., Portugal, L. et al. Laryngotracheal Involvement in Systemic Light Chain Amyloidosis. Head and Neck Pathol 12, 127–130 (2018). https://doi.org/10.1007/s12105-017-0831-0

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  • DOI: https://doi.org/10.1007/s12105-017-0831-0

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