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Langerhans Cell Histiocytosis of the Temporal Bone

  • Sine qua non Radiology-Pathology
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Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.

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Authors and Affiliations

  1. Department of Radiology, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA

    Daniel Thomas Ginat

  2. Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA

    Daniel N. Johnson & Nicole A. Cipriani

Authors
  1. Daniel Thomas Ginat
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  2. Daniel N. Johnson
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  3. Nicole A. Cipriani
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Correspondence to Daniel Thomas Ginat.

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Ginat, D.T., Johnson, D.N. & Cipriani, N.A. Langerhans Cell Histiocytosis of the Temporal Bone. Head and Neck Pathol 10, 209–212 (2016). https://doi.org/10.1007/s12105-015-0629-x

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  • DOI: https://doi.org/10.1007/s12105-015-0629-x

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