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Collision Tumor of Primary Laryngeal Mucosal Melanoma and Invasive Squamous Cell Carcinoma with IL-17A and CD70 Gene Over-Expression

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Abstract

The most common primary malignancy of the larynx is the squamous cell carcinoma (SCC). The primary malignant melanoma is quite rare in this location. Less than 60 cases of laryngeal melanomas have been reported to date. To our knowledge, collision primary malignant melanoma and invasive squamous cell carcinoma in the vocal cords has not been reported. We report a 53-year-old male patient who was diagnosed with a collision tumor of laryngeal melanoma and invasive SCC. Multiple Th17 pathway related genes including CTLA-4, IL-17A-F, PLZF, FoxP3, RorγT, CD27, and CD70 were analyzed by reverse transcriptase-polymerase chain reaction (Rt–PCR) in this case. Both IL-17A and CD70 genes were detected in this case of collision tumor. The results may define useful biomarkers for early diagnosis of mucosal melanoma and open an immunotherapeutic field for clinical management with the potential benefit from the immunomodulators that enhance both genes.

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine, 550 First Avenue, TCH-461, New York, NY, 10016, USA

    Sasis Sirikanjanapong & Beverly Y. Wang

  2. Department of Otolaryngology, New York University School of Medicine, New York, USA

    Biana Lanson, Milan Amin & Beverly Y. Wang

  3. Department of Medicine, New York University School of Medicine, New York, USA

    Frank Martiniuk

  4. Department of Dermatopathology, New York University School of Medicine, New York, USA

    Hideko Kamino

Authors
  1. Sasis Sirikanjanapong
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  2. Biana Lanson
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  3. Milan Amin
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  4. Frank Martiniuk
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  5. Hideko Kamino
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  6. Beverly Y. Wang
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Correspondence to Beverly Y. Wang.

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Funded by grant number: NIH/NCRR 1UL1RR029893-01.

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Sirikanjanapong, S., Lanson, B., Amin, M. et al. Collision Tumor of Primary Laryngeal Mucosal Melanoma and Invasive Squamous Cell Carcinoma with IL-17A and CD70 Gene Over-Expression. Head and Neck Pathol 4, 295–299 (2010). https://doi.org/10.1007/s12105-010-0200-8

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  • DOI: https://doi.org/10.1007/s12105-010-0200-8

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