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A Case of Recurrent Multifocal Central Giant Cell Granulomas

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Abstract

One case of recurrent multifocal central giant cell granulomas (CGCG) is presented. Initially, the lesions presented concurrently in the maxilla and mandible with subsequent recurrence in the mandible. Now, two recurrences are seen in the maxillary sinus and ethmoid region. The literature regarding multifocal CGCG is reviewed.

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References

  1. Motamedi MH, Eshghyar N, Jafari SM, et al. Peripheral and central giant cell granulomas of the jaws: a demographic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:39–43. doi:10.1016/j.tripleo.2006.12.022.

    Article  Google Scholar 

  2. Waldron CA, Shafer WG. The central giant cell reparative granuloma of the jaws: an analysis of 38 cases. Am J Clin Pathol. 1966;45:437–47.

    PubMed  CAS  Google Scholar 

  3. Whitaker SB, Waldron CA. Central giant cell lesions of the jaws: a clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol. 1993;75:199–208. doi:10.1016/0030-4220(93)90094-K.

    Article  PubMed  CAS  Google Scholar 

  4. Kaffe I, Ardekian L, Taicher S, et al. Radiologic features of central giant cell granuloma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:720–6. doi:10.1016/S1079-2104(96)80079-5.

    Article  PubMed  CAS  Google Scholar 

  5. Lorenzo JC, Dorfman HD. Giant-cell reparative granuloma of short tubular bones of the hands and feet. Am J Surg Pathol. 1980;4:551–63. doi:10.1097/00000478-198012000-00006.

    Article  PubMed  CAS  Google Scholar 

  6. Glass TA, Mills SE, Fechner RE, et al. Giant-cell reparative granuloma of the hands and feet. Radiology. 1983;149:65–8.

    PubMed  CAS  Google Scholar 

  7. De Lange J, Van den Akker HP. Clinical and radiological features of central giant-cell lesions of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:464–70. doi:10.1016/j.tripleo.2004.11.015.

    Article  PubMed  Google Scholar 

  8. Kruse-Losler B, Diallo R, Gaertner C, et al. Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:346–54. doi:10.1016/j.tripleo.2005.02.060.

    Article  PubMed  Google Scholar 

  9. Ardekian L, Manor R, Peled M, et al. Bilateral central giant cell granulomas in a patient with neurofibromatosis: report of a case and review of the literature. J Oral Maxillofac Surg. 1999;57:869–72. doi:10.1016/S0278-2391(99)90833-9.

    Article  PubMed  CAS  Google Scholar 

  10. Ruggieri M, Pavone V, Polizzi A, et al. Unusual form of recurrent giant cell granuloma of the mandible and lower extremities in a patient with neurofibromatosis type 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:67–72. doi:10.1016/S1079-2104(99)70297-0.

    Article  PubMed  CAS  Google Scholar 

  11. Edwards PC, Fantasia JE, Saini T, et al. Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:765–72. doi:10.1016/j.tripleo.2005.10.038.

    Article  PubMed  Google Scholar 

  12. Cohen MM Jr, Gorlin RJ. Noonan-like/multiple giant cell lesion syndrome. Am J Med Genet. 1991;40:159–66. doi:10.1002/ajmg.1320400208.

    Article  PubMed  Google Scholar 

  13. Cancino CM, Gaiao L, Sant’Ana Filho M, et al. Giant cell lesions with a Noonan-like phenotype: a case report. J Contemp Dent Pract. 2007;8:67–73.

    PubMed  Google Scholar 

  14. van Damme PA, Mooren RE. Differentiation of multiple giant-cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism: case report and review of the literature. Int J Oral Maxillofac Surg. 1994;23:32–6. doi:10.1016/S0901-5027(05)80323-6.

    Article  PubMed  Google Scholar 

  15. Stolovitzky JP, Waldron CA, McConnel FMS. Giant cell lesions of the maxilla and paranasal sinuses. Head Neck. 1994;16:143–8. doi:10.1002/hed.2880160207.

    Article  PubMed  CAS  Google Scholar 

  16. Terry BC, Jacoway JR. Management of central giant cell lesions: an alternative to surgical therapy. Oral Maxillofac Surg Clin North Am. 1994;6:579–600.

    Google Scholar 

  17. de Lange J, van den Akker HP, Veldhuijzen van Zanten GO, et al. Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. Int J Oral Maxillofac Surg. 2006;35:791–5. doi:10.1016/j.ijom.2006.03.030.

    Article  PubMed  Google Scholar 

  18. de Lange J, van den Akker HP, van den Berg H, et al. Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. Int J Oral Maxillofac Surg. 2006;35:865–9. doi:10.1016/j.ijom.2006.02.011.

    Article  PubMed  Google Scholar 

  19. Kaban LB, Troulis MJ, Ebb D, et al. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002;60:1103–11. doi:10.1053/joms.2002.34975.

    Article  PubMed  Google Scholar 

  20. Bernick S. Central giant cell tumors of the jaws. J Oral Surg. 1948;6:324.

    PubMed  CAS  Google Scholar 

  21. Jaffe H. Giant cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jaw bones. Oral Surg Oral Med Oral Pathol. 1953;6:159–75. doi:10.1016/0030-4220(53)90151-0.

    Article  PubMed  CAS  Google Scholar 

  22. Shklar G, Meyer I. A giant-cell tumor of the maxilla in an area of osteitis deformans (Paget’s disease of bone). Oral Surg Oral Med Oral Pathol. 1958;11:835–42. doi:10.1016/0030-4220(58)90198-1.

    Article  PubMed  CAS  Google Scholar 

  23. Austin L, Dahlin D, Royer R. Giant-cell reparative granuloma and related conditions affecting the jawbones. Oral Surg Oral Med Oral Pathol. 1959;12:1285–95. doi:10.1016/0030-4220(59)90215-4.

    Article  PubMed  Google Scholar 

  24. Abrams B, Shear M. A histological comparison of the giant cells in central giant cell granuloma of the jaws and the giant cell tumor of long bone. J Oral Pathol. 1974;3:217–23. doi:10.1111/j.1600-0714.1974.tb01714.x.

    Article  PubMed  CAS  Google Scholar 

  25. Auclair PL, Kratochvil FJ, Slater LJ, et al. A clinical and histomorphologic comparison of the central giant cell granuloma and giant cell tumor. Oral Surg Oral Med Oral Pathol. 1988;66:197–208. doi:10.1016/0030-4220(88)90094-1.

    Article  PubMed  CAS  Google Scholar 

  26. Cohen MM Jr, Gorlin RJ. Noonan-like/multiple giant cell lesion syndrome. Am J Med Genet. 1991;40:159–66. doi:10.1002/ajmg.1320400208.

    Article  PubMed  Google Scholar 

  27. Regezi JA, Zarbo RJ, Lloyd RV. Muramidase, alpha-1 antitrypsin, alpha-1 antichymotrypsin, and S-100 protein immunoreactivity in giant cell lesions. Cancer. 1987;59:64–8. doi:10.1002/1097-0142(19870101)59:1<64::AID-CNCR2820590116>3.0.CO;2-Q.

    Article  PubMed  CAS  Google Scholar 

  28. O’Malley M, Pogrel MA, Stewart JC, et al. Central giant cell granulomas of the jaws: phenotype and proliferation-associated markers. J Oral Pathol Med. 1997;26:159–63. doi:10.1111/j.1600-0714.1997.tb00451.x.

    Article  PubMed  Google Scholar 

  29. Tobon-Arroyave SI, Franco-Gonzalez LM, Isaza-Guzman DM, et al. Immunohistochemical expression of RANK, GRalpha and CTR in central giant cell granuloma of the jaws. Oral Oncol. 2005;41:480–8. doi:10.1016/j.oraloncology.2004.11.006.

    Article  PubMed  CAS  Google Scholar 

  30. Wang C, Song Y, Peng B, et al. Expression of c-Src and comparison of cytologic features in cherubism, central giant cell granuloma and giant cell tumors. Oncol Rep. 2006;15:589–94.

    PubMed  CAS  Google Scholar 

  31. Lietman SA, Prescott NL, Hicks DG, et al. SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism. Clin Orthop Relat Res. 2007;459:22–7. doi:10.1097/BLO.0b013e31804b4131.

    Article  PubMed  Google Scholar 

  32. Lee CH, Espinosa I, Jensen KC, et al. Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone. Mod Pathol. 2008;21:531–9. doi:10.1038/modpathol.3801023.

    Article  PubMed  CAS  Google Scholar 

  33. Dickson BC, Li SQ, Wunder JS, et al. Giant cell tumor of bone express p63. Mod Pathol. 2008;21:369–75. doi:10.1038/modpathol.2008.29.

    Article  PubMed  CAS  Google Scholar 

  34. Miloro M, Quinn PD. Synchronous central giant cell lesions of the jaws: report of a case and review of the literature. J Oral Maxillofac Surg. 1995;53:1350–5. doi:10.1016/0278-2391(95)90600-2.

    Article  PubMed  CAS  Google Scholar 

  35. Martins WD, de Oliveira Ribas M, Braosi AP, et al. Multiple giant cell lesions of the maxillofacial skeleton. J Oral Maxillofac Surg. 2007;65:1250–3. doi:10.1016/j.joms.2005.10.046.

    Article  PubMed  Google Scholar 

  36. Cassatly MG, Greenberg AM, Kopp WK. Bilateral giant cell granulomata of the mandible: report of a case. J Am Dent Assoc. 1988;117:731–3.

    PubMed  CAS  Google Scholar 

  37. Weldon L, Cozzi G. Multiple giant cell lesions of the jaws. J Oral Maxillofac Surg. 1982;40:520–2. doi:10.1016/0278-2391(82)90016-7.

    Article  PubMed  CAS  Google Scholar 

  38. Curtis NJ, Walker DM. A case of aggressive multiple metachronous central giant cell granulomas of the jaws: differential diagnosis and management options. Int J Oral Maxillofac Surg. 2005;34:806–8. doi:10.1016/j.ijom.2005.01.010.

    Article  PubMed  CAS  Google Scholar 

  39. Davis JP, Archer DJ, Fisher C, et al. Multiple recurrent giant cell lesions associated with high circulating levels of parathyroid hormone-related peptide in a young adult. Br J Oral Maxillofac Surg. 1991;29:102–5. doi:10.1016/0266-4356(91)90092-J.

    Article  PubMed  CAS  Google Scholar 

  40. Smith PG, Marrogi AJ, Delfino JJ. Multifocal central giant cell lesions of the maxillofacial skeleton: a case report. J Oral Maxillofac Surg. 1990;48:300–5. doi:10.1016/0278-2391(90)90398-L.

    Article  PubMed  CAS  Google Scholar 

  41. Struthers PJ, Shear M. Aneurysmal bone cyst of the jaws. (II). Pathogenesis. Int J Oral Surg. 1984;13:92–100. doi:10.1016/S0300-9785(84)80078-2.

    Article  PubMed  CAS  Google Scholar 

  42. Levy W, Miller A, Bonakdarpour A, et al. Aneurysmal bone cyst secondary to other osseous lesions: report of 57 cases. Am J Clin Pathol. 1975;63:1–8.

    PubMed  CAS  Google Scholar 

  43. Davis GB, Tideman H. Multiple recurrent central giant cell granulomas of the jaws. J Maxillofac Surg. 1977;5:127–9. doi:10.1016/S0301-0503(77)80089-1.

    Article  PubMed  CAS  Google Scholar 

  44. Loukota RA. Metachronous and recurrent central giant cell granulomas: a case report. Br J Oral Maxillofac Surg. 1991;29:48–50. doi:10.1016/0266-4356(91)90175-5.

    Article  PubMed  CAS  Google Scholar 

  45. Wise AJ, Bridbord JW. Giant cell granuloma of the facial bones. Ann Plast Surg. 1993;30:564–8. doi:10.1097/00000637-199306000-00019.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors would like to thank Drs. Leon Barnes, Simion Chiosea, and Raja Seethala for their comments on this paper.

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Authors and Affiliations

  1. Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA

    Elizabeth Bilodeau & Bobby Collins

  2. Center for Craniofacial & Skull Base Disorders/Department of Otolaryngology, University of Colorado, Denver, CO, USA

    Khalid Chowdhury

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  1. Elizabeth Bilodeau
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Correspondence to Elizabeth Bilodeau.

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Bilodeau, E., Chowdhury, K. & Collins, B. A Case of Recurrent Multifocal Central Giant Cell Granulomas. Head and Neck Pathol 3, 174–178 (2009). https://doi.org/10.1007/s12105-009-0119-0

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  • DOI: https://doi.org/10.1007/s12105-009-0119-0

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