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Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1

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Abstract

The voltage dependent anion channel (VDAC) forms a channel for metabolites and nutrients in the outer membrane of mitochondria, and it is also involved in apoptotic pathways. Here, we report sequence-specific NMR assignments for the isoform 1 of human VDAC reconstituted in lauryldimethylamine oxide (LDAO) detergent micelles. The assignments were deposited in the BMRB data base with accession number 16381.

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Acknowledgments

This work was supported by the United States National Institute of Health by the roadmap grant GM075879 and the grants GM066360, GM47467 and EB 002026 for purchase, operation and maintenance of the instruments. S.H. was supported in part by the Swiss National Science Foundation.

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Author notes

  1. Sebastian Hiller

    Present address: Laboratory of Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland

  2. Thomas J. Malia

    Present address: Centocor, Inc., Radnor, PA, 19087, USA

Authors and Affiliations

  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA

    Sebastian Hiller, Thomas J. Malia, Robert G. Garces, Vladislav Y. Orekhov & Gerhard Wagner

  2. Swedish NMR Centre, University of Gothenborg, Box 465, Gothenborg, 40530, Sweden

    Vladislav Y. Orekhov

Authors
  1. Sebastian Hiller
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  2. Thomas J. Malia
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  3. Robert G. Garces
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  4. Vladislav Y. Orekhov
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  5. Gerhard Wagner
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Corresponding author

Correspondence to Gerhard Wagner.

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Hiller, S., Malia, T.J., Garces, R.G. et al. Backbone and ILV side chain methyl group assignments of the integral human membrane protein VDAC-1. Biomol NMR Assign 4, 29–32 (2010). https://doi.org/10.1007/s12104-009-9194-0

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  • DOI: https://doi.org/10.1007/s12104-009-9194-0

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