Abstract
Elizabethkingia, an emerging nosocomial pathogen is a gram-negative bacillus causing NICU outbreaks. This case series from a tertiary care hospital, South India describes the clinical profile and outcome of 92 neonates with culture-positive elizabethkingia sepsis over a period of 2 y. Elizabethkingia sepsis predominantly affected preterm neonates and the common clinical features were respiratory distress, apnea, and poor feeding. Meningitis was noted in 68% and mortality was 12%. Antimicrobial susceptibility testing showed that elizabethkingia was susceptible to minocycline and levofloxacin.
References
Ceyhan M, Celik M. Elizabethkingia meningosepticum (Chryseobacteriummeningosepticum) infections in children. Int J Pediatr. 2011;2011:215237.
Lau SK, Chow WN, Foo CH, et al. Elizabethkingia anopheles bacteremia is associated with clinically significant infections and high mortality. Sci Rep. 2016;6:26045.
Seong H, Kim JH, Kim JH, et al. Risk factors for mortality in patients with elizabethkingia infection and the clinical impact of the antimicrobial susceptibility patterns of elizabethkingia species. J Clin Med. 2020;9:1431.
Kumar C, Sastry AS, Plakkal N. Neonatal sepsis and meningitis caused by elizabethkingia. Indian J Pediatr. 2021;88:598.
Perrin A, Larsonneur E, Nicholson AC, et al. Evolutionary dynamics and genomic features of the elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. Nat Commun. 2017;8:15483.
Frank T, Gody JC, Nguyen LB, et al. First case of elizabethkingia anophelis meningitis in the Central African Republic. Lancet. 2013;381:1876.
Lin JN, Lai CH, Yang CH, et al. Clinical manifestations, molecular characteristics, antimicrobial susceptibility patterns and contributions of target gene mutation to fluoroquinolone resistance in Elizabethkingia anophelis. J Antimicrob Chemother. 2018;73:2497–502.
Honavar AG, David A, Amladi A, Thomas L. Multidrug-resistant elizabethkingia anophelis septicemia, meningitis, ventriculitis, and hydrocephalus in a preterm neonate: A rare complication of an emerging pathogen. J Pediatr Neurosci. 2021;16:79–81.
Chang Y, Zhang D, Niu S, Chen Q, Lin Q, Zhang X. MBLs, rather than efflux pumps, led to carbapenem resistance in fosfomycin and aztreonam/avibactam resistant elizabethkingia anophelis. Infect Drug Resist. 2021;14:315–27.
Burnard D, Gore L, Henderson A, et al. Comparative genomics and antimicrobial resistance profiling of elizabethkingia isolates reveal nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines, and trimethoprim-sulfamethoxazole. J Clin Microbiol. 2020;58:e00730–e820.
Acknowledgements
The authors thank the members of the Department of Neonatology, Microbiology and the Medical Records Department for their assistance in data collection. They also thank the PSM department for their help in data handling and analysis.
Funding
JIPMER GJ STRAUS Project No: JIP/UGRMC/GJSTRAUS/2022/3.
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AMA collected and analyzed the data and drafted the manuscript; AB conceptualized and designed the study, edited manuscript; ASS helped with lab investigations. AB will act as the guarantor for this paper.
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Anil, A.M., B., A. & Sastry, A.S. Clinical Profile and Outcome of Neonates with Elizabethkingia Sepsis. Indian J Pediatr 90, 612–614 (2023). https://doi.org/10.1007/s12098-022-04467-8
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DOI: https://doi.org/10.1007/s12098-022-04467-8