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Vitamin D Status in Infants with Two Different Wheezing Phenotypes

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Abstract

Objective

To investigate vitamin D levels in patients with recurrent wheeze at early ages of childhood.

Methods

In the present cross-sectional study, serum 25-hydroxy vitamin D [25 (OH)D], levels which is known as an indicator of vitamin D adequacy, was examined in infants with three or more wheezing attacks.

Results

A total of 186 infants with recurrent wheezing were included in the study along with 118 healthy control peers. The recurrent wheezing study participants were classified into two groups according to Asthma Predictive Index (API) positivity and compared to control subjects regarding their serum vitamin D status. The API negative group had the lowest mean serum 25 (OH)D level (n = 121; 22.71 ± 10.76 ng/ml) followed by API positive group (n = 65; 24.08 ± 9.02 ng/ml) compared to healthy group (26.24 ± 11.88 ng/ml) (p < 0.05). In addition, higher vitamin D deficiency was observed in infants in API negative group (52.1 %; p < 0.01) and API positive group (38.5 %; p < 0.05) than control group (31.4 %).

Conclusions

Low levels of 25 (OH)D were detected in infants with two different phenotypes of recurrent wheeze. Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing.

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Acknowledgments

The authors would like to thank Prof Mark Brown for reviewing the manuscript.

Contributions

AO is the primary investigator and made substantial contribution to conception, data interpretation and design of the study. DD made substantial contribution in accessing the statistical analysis and preparation of the manuscript. OY made substantial contribution in patient enrollment to the study and preparation of the manuscript. All authors read and approved the final version of the manuscript. AO will act as guarantor for the paper.

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Authors and Affiliations

  1. Pediatric Pulmonary Section, Department of Pediatrics, Mersin Children’s Hospital, Halkkent, 33240, Mersin, Turkey

    Ali Ozdemir

  2. Pediatric Allergy & Immunology Section, Department of Pediatrics, University of Baskent, Adana, Turkey

    Dilek Dogruel

  3. Pediatric Allergy & Immunology Section, Department of Pediatrics, Mersin Children’s Hospital, Halkkent, Mersin, Turkey

    Ozlem Yilmaz

Authors
  1. Ali Ozdemir
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  2. Dilek Dogruel
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  3. Ozlem Yilmaz
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Correspondence to Ali Ozdemir.

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Ozdemir, A., Dogruel, D. & Yilmaz, O. Vitamin D Status in Infants with Two Different Wheezing Phenotypes. Indian J Pediatr 83, 1386–1391 (2016). https://doi.org/10.1007/s12098-016-2184-1

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  • DOI: https://doi.org/10.1007/s12098-016-2184-1

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