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Serum Bisphenol A Concentration and Premature Thelarche in Female Infants Aged 4-month to 2-year

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Abstract

Objectives

To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.

Methods

A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.

Results

Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06–51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.

Conclusions

This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.

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Acknowledgments

The authors would like to thank the children and their parents who participated in the study.

Contributions

LHC, YLF, LL: Conceived and designed the research; JRS, WQC, XZC: Collected the data; LHC, YLF: Analyzed the data; YLF: Act as guarantor for this paper; LHC, JRS, YLF: Wrote the paper.

Conflict of Interest

None.

Source of Funding

The Medical Science and Technology Program of Zhejiang province (2012RCA039) funded the study.

Author information

Authors and Affiliations

  1. Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China

    Lian-hui Chen, Yan-lan Fang & Li Liang

  2. Laboratory Center of Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Jian-rong Shi

  3. Zhejiang Quality Inspection Institute of Science, Hangzhou, China

    Wan-qin Chen & Xiao-zhen Chen

Authors
  1. Lian-hui Chen
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  2. Jian-rong Shi
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  3. Yan-lan Fang
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  4. Li Liang
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  5. Wan-qin Chen
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Corresponding author

Correspondence to Yan-lan Fang.

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Chen, Lh., Shi, Jr., Fang, Yl. et al. Serum Bisphenol A Concentration and Premature Thelarche in Female Infants Aged 4-month to 2-year. Indian J Pediatr 82, 221–224 (2015). https://doi.org/10.1007/s12098-014-1548-7

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  • DOI: https://doi.org/10.1007/s12098-014-1548-7

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