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Overview of Alternaria alternata Membrane Proteins

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Abstract

Alternaria species are mainly saprophytic fungi, but some pathotypes of Alternaria alternata infect economically important plants including cereal crops, vegetables and fruits. Specially, A. alternata generates toxins which contaminate food and feed. To date, management of A. alternata relies primarily on fungicides. However, the control efficacy in most cases is below expectation due to ubiquity of A. alternata and resistance to fungicides. To mitigate resistance and develop long-lasting fungicides, uncovering multiple rather than single target is a prerequisite. Membrane proteins are potential targets of fungicides owing to wide participation in myriad biochemical events especially material transport, signal transduction and pathogenicity. However, so far, little is known about the distribution and molecular structure of A. alternata membrane proteins (AAMPs). Herein we summarize AAMPs by data mining and subsequent structure prediction. We also outline the state-of-the-art research advances of AAMPs especially those closely related to pathogenicity. Overall, this review aims to portray a picture of AAMPs and provide valuable insights for future development of highly efficient fungicides towards A. alternata or beyond.

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Acknowledgements

This work was supported by grants from Key Research and Development Program of Hebei Province (19226509D), Project of Beijing Municipal Commission of Education (KZ201911417049), Premium Funding Project for Academic Human Resources Development in Beijing Union University (BPHR2018BZ01), and National Natural Science Foundation of China (21476011).

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  1. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People’s Republic of China

    Ruyi Wang, Peng Zhao & Pingfang Tian

  2. College of Biochemical Engineering, Beijing Union University, Beijing, 100023, People’s Republic of China

    Xizhen Ge

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Wang, R., Zhao, P., Ge, X. et al. Overview of Alternaria alternata Membrane Proteins. Indian J Microbiol 60, 269–282 (2020). https://doi.org/10.1007/s12088-020-00873-8

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