Skip to main content

Advertisement

SpringerLink
Log in

Higher prevalence of chronic kidney disease and shorter renal survival in patients with chronic hepatitis C virus infection

  • Original Article
  • Published:
Hepatology International Aims and scope Submit manuscript

Abstract

Background

The role of hepatitis C virus infection (HCV) in the etiology and progression of chronic kidney disease (CKD) is controversial.

Aim

To measure the prevalence of CKD and evaluate its course in patients with chronic HCV infection.

Methods

A retrospective analysis was done after excluding patients with nephrolithiasis, structural kidney disease, and those with missing clinical information on 552 anti-HCV-positive patients and 313 patients without known HCV infection matched for age, race, and gender. CKD was defined as estimated glomerular filtration rate value of <60 mL/min/1.73 m2 and/or persistence of proteinuria (>3 months) on urine analysis by dipstick. Viral load obtained during the initial evaluation was defined as “baseline viral load”.

Results

The prevalence of CKD in the anti-HCV-positive group was significantly higher compared to control group [53 (9.6%) vs. 16 (5.1%), P = 0.02]. On multivariate regression analysis, higher age, hypertension, HCV PCR > 7 × 105 cps/mL, and diabetes mellitus were significant independent positive predictors, whereas history of interferon treatment was significant independent negative predictor for CKD. Male gender, human immunodeficiency virus status, body weight, intravenous drug use, and HCV genotype were not predictors of CKD. Analysis of renal survival through Kaplan–Meyer curves revealed significantly shorter time to develop CKD (74 vs. 84 months, P < 0.001; log rank) and end-stage renal disease (79.9 vs. 86.5 months, P = 0.005; log rank) in the HCV group compared to the control group.

Conclusion

Chronic HCV infection was associated with a significantly higher prevalence of CKD compared with controls, as well as significantly shorter renal survival. A higher baseline viral load is an independent predictor of CKD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Sabry AA, Sobh MA, Irving WL, et al. A comprehensive study of the association between hepatitis C virus and glomerulopathy. Nephrol Dial Transplant 2002;17:239–245

    Article  PubMed  Google Scholar 

  2. Kamar N, Izopet J, Alric L, Guilbeaud-Frugier C, Rostaing L. Hepatitis C virus-related kidney disease: an overview. Clin Nephrol 2008;69:149–160

    PubMed  CAS  Google Scholar 

  3. Cao Y, Zhang Y, Wang S, Zou W. Detection of the hepatitis C virus antigen in kidney tissue from infected patients with various glomerulonephritis. Nephrol Dial Transplant 2009;24:2745–2751

    Article  PubMed  CAS  Google Scholar 

  4. Tsui JI, Vittinghoff E, Shlipak MG, O’Hare AM. Relationship between hepatitis C and chronic kidney disease: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol 2006;17:1168–1174

    Article  PubMed  Google Scholar 

  5. Liangpunsakul S, Chalasani N. Relationship between hepatitis C and microalbuminuria: results from the NHANES III. Kidney Int 2005;67:285–290

    Article  PubMed  Google Scholar 

  6. Tsui JI, Vittinghoff E, Shlipak MG, et al. Association of hepatitis C seropositivity with increased risk for developing end-stage renal disease. Arch Intern Med 2007;167:1271–1276

    Article  PubMed  Google Scholar 

  7. Fabrizi F, Marcelli D, Bacchini G, Guarnori I, Erba G, Locatelli F. Antibodies to hepatitis C virus (HCV) in chronic renal failure (CRF) patients on conservative therapy: prevalence, risk factors and relationship to liver disease. Nephrol Dial Transplant 1994;9:780–784

    PubMed  CAS  Google Scholar 

  8. Soma J, Saito T, Taguma Y, et al. High prevalence and adverse effect of hepatitis C virus infection in type II diabetic-related nephropathy. J Am Soc Nephrol 2000;11:690–699

    PubMed  CAS  Google Scholar 

  9. Crook ED, Penumalee S, Gavini B, Filippova K. Hepatitis C is a predictor of poorer renal survival in diabetic patients. Diabetes Care 2005;28:2187–2191

    Article  PubMed  Google Scholar 

  10. Kasuno K, Ono T, Matsumori A, et al. Hepatitis C virus-associated tubulointerstitial injury. Am J Kidney Dis 2003;41:767–775

    Article  PubMed  Google Scholar 

  11. Sansonno D, Lauletta G, Montrone M, Grandaliano G, Schena FP, Dammacco F. Hepatitis C virus RNA and core protein in kidney glomerular and tubular structures isolated with laser capture microdissection. Clin Exp Immunol 2005;140:498–506

    Article  PubMed  CAS  Google Scholar 

  12. Moe SM, Pampalone AJ, Ofner S, Rosenman M, Teal E, Hui SL. Association of hepatitis C virus infection with prevalence and development of kidney disease. Am J Kidney Dis 2008;51:885–892

    Article  PubMed  CAS  Google Scholar 

  13. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39:S1–S266

    Google Scholar 

  14. Mehta SH, Brancati FL, Strathdee SA, et al. Hepatitis C virus infection and incident type 2 diabetes. Hepatology 2003;38:50–56

    Article  PubMed  Google Scholar 

  15. Mehta SH, Brancati FL, Sulkowski MS, Strathdee SA, Szklo M, Thomas DL. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000;133:592–599

    PubMed  CAS  Google Scholar 

  16. Fabrizi F, Pozzi C, Farina M, et al. Hepatitis C virus infection and acute or chronic glomerulonephritis: an epidemiological and clinical appraisal. Nephrol Dial Transplant 1998;13:1991–1997

    Article  PubMed  CAS  Google Scholar 

  17. Johnson RJ, Gretch DR, Yamabe H, et al. Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 1993;328:465–470

    Article  PubMed  CAS  Google Scholar 

  18. Daghestani L, Pomeroy C. Renal manifestations of hepatitis C infection. Am J Med 1999;106:347–354

    Article  PubMed  CAS  Google Scholar 

  19. Fukui M, Kitagawa Y, Nakamura N, Yoshikawa T. Hepatitis C virus and atherosclerosis in patients with type 2 diabetes. JAMA 2003;289:1245–1246

    Article  PubMed  Google Scholar 

  20. Ishizaka N, Ishizaka Y, Takahashi E, et al. Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening. Lancet 2002;359:133–135

    Article  PubMed  Google Scholar 

  21. Vassalle C, Masini S, Bianchi F, Zucchelli GC. Evidence for association between hepatitis C virus seropositivity and coronary artery disease. Heart 2004;90:565–566

    Article  PubMed  CAS  Google Scholar 

  22. Taskapan H, Oymak O, Dogukan A, Utas C. Patient to patient transmission of hepatitis C virus in hemodialysis units. Clin Nephrol 2001;55:477–481

    PubMed  CAS  Google Scholar 

  23. Bergman S, Accortt N, Turner A, Glaze J. Hepatitis C infection is acquired pre-ESRD. Am J Kidney Dis 2005;45:684–689

    Article  PubMed  Google Scholar 

  24. Sterling RK, Sanyal AJ, Luketic VA, et al. Chronic hepatitis C infection in patients with end stage renal disease: characterization of liver histology and viral load in patients awaiting renal transplantation. Am J Gastroenterol 1999;94:3576–3582

    Article  PubMed  CAS  Google Scholar 

  25. Hatoum HH, Rzouq F. The Direct Impact of Hepatitis C Viral Load on Kidney Function. ACG 2009; Abstract P192

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, New York Medical College/Metropolitan Hospital Center, New York, 10029, USA

    Sanjaya Kumar Satapathy & Chandra Sekhar Lingisetty

  2. Department of Gastroenterology, New York Medical College/Metropolitan Hospital Center, 1901 First Avenue, New York, 10029, USA

    Susan Williams

Authors
  1. Sanjaya Kumar Satapathy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chandra Sekhar Lingisetty
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Susan Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susan Williams.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Satapathy, S.K., Lingisetty, C.S. & Williams, S. Higher prevalence of chronic kidney disease and shorter renal survival in patients with chronic hepatitis C virus infection. Hepatol Int 6, 369–378 (2012). https://doi.org/10.1007/s12072-011-9284-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12072-011-9284-9

Keywords

Search

Navigation