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Correlation Between Nasal Allergy and the Number of Eosinophils in Adenoid Tissue

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

To study adenoid tissue eosinophilia in allergic rhinitis. A single-centre clinical case–control prospective study with 66 subjects enrolled for the study after taking written informed consent from all the participants. All patients underwent adenoidectomy with histopathological evaluation of adenoid tissue samples for eosinophils. 36 patients (cases) with Symptoms for Allergic Rhinitis (SFAR) score indicative of allergic rhinitis. 30 patients (control) with SFAR scores not indicative of allergic rhinitis. All patients were evaluated for serum absolute eosinophil count and total serum immunoglobulin E (Ig-E). There was a significant relationship between allergic rhinitis and serum Ig-E levels using the Kruskal–Wallis rank sum test amongst case and control groups with a p-value of 0.031. Pathologically examined slides of adenoid tissue eosinophil count per 10 random high power fields in these patients showed significant results with a p-value of 0.002432, via the Kruskal–Wallis rank sum test. Statistical analysis, shows that adenoid tissue eosinophil count and serum Ig-E levels can somewhat predict the presence of clinical features of allergic rhinitis. Based on several similar studies with similar results, allergic rhinitis can be gauged with adenoid tissue histopathology and routine evaluation should be considered as a standard of care.

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References

  1. Evcimik MF, Dogru M, Cirik AA, Nepesov MI (2015) Adenoid hypertrophy in children with allergic disease and influential factors. Int J Pediatr Otorhinolaryngol 79(5):694–7. https://doi.org/10.1016/j.ijporl.2015.02.017

    Article  PubMed  Google Scholar 

  2. Yucel N, Görgülü O, Yucel G, Külahc Ö, Kür O (2018) Can the number of eosinophils in adenoid and tonsil tissue determine the allergy in children? Int J Pediatr Otorhinolaryngol 108:35–9

    Article  PubMed  Google Scholar 

  3. Modrzynski M, Zawisza E (2007) An analysis of the incidence of adenoid hypertrophy in allergic children. Int J Pediatr Otorhinolaryngol 71(5):713–719

    Article  PubMed  Google Scholar 

  4. Ameli F, Brocchetti F, Tosca MA, Schiavetti I, Ciprandi G (2014) Tonsil volume and allergic rhinitis in children. Allergy Rhinol 5(3):137–142

    Article  Google Scholar 

  5. Fokkens WJ, Vinke JG, De Jong SS, Bogaert DPVD, Kleinjan A, Eichhorn E (1998) Differences in cellular infiltrates in the adenoid of allergic children compared with age- and gender-matched controls. Clin Exp Allergy 28(2):187–195

    Article  CAS  PubMed  Google Scholar 

  6. Annesi-Maesano I, Didier A, Klossek M, Chanal I, Moreau D, Bousquet J (2002) The score for allergic rhinitis (SFAR): a simple and valid assessment method in population studies. Allergy 57(2):107–114

    Article  CAS  PubMed  Google Scholar 

  7. Supakthanasiri P, Klaewsongkram J, Chantaphakul H (2014) Reactivity of allergy skin test in healthy volunteers. Singapore Med J 55:34

    Article  PubMed  PubMed Central  Google Scholar 

  8. Brunetto B, Tinghino R, Braschi MC, Antonicelli L, Pini C, Iacovacci P (2010) Characterization and comparison of commercially available mite extracts for in vivo diagnosis. Allergy Eur J Allergy Clin Immunol 65:184–190

    Article  CAS  Google Scholar 

  9. Payne SC, Early SB, Huyett P, Han JK, Borish L, Steinke JW (2011) Evidence for a distinct histologic profile of nasal polyps with and without eosinophilia. Laryngoscope 121:2262–2267

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kemaloglu YK, Inal E, Goksu N, Akyildiz N (1999) Radiographic evaluation of children with nasopharyngeal obstruction due to the adenoid. Ann Otol Rhinol Laryngol 108:67–72

    Article  CAS  PubMed  Google Scholar 

  11. Fujioka M, Young LW, Girdany BR (1979) Radiographic evaluation of adenoidal size in children: adenoidal-nasopharyngeal ratio. Am J Roentgenol 133:401–404

    Article  CAS  Google Scholar 

  12. Scadding G (2010) Non-surgical treatment of adenoidal hypertrophy: The role of treating IgE-mediated inflammation. Pediatr Allergy Immunol 21:1095–1106

    Article  PubMed  Google Scholar 

  13. Chawes BLK (2011) Upper and lower airway pathology in young children with allergic- and non-allergic rhinitis. Dan Med Bull 58:B4278

    PubMed  Google Scholar 

  14. Zhang X, Sun B, Li S, Jin H, Zhong N, Zeng G (2013) Local atopy is more relevant than serum sIgE in reflecting allergy in childhood adenotonsillar hypertrophy. Pediatr Allergy Immunol 24(5):422–426

    Article  PubMed  Google Scholar 

  15. Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ et al (2011) Clinical practice guideline: tonsillectomy in children. Otolaryngol Head Neck Surg 144:S1–S30

    Article  PubMed  Google Scholar 

  16. Nguyen LHP, Manoukian JJ, Sobol SE, Tewfik TL, Mazer BD, Schloss MD et al (2004) Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol 114(5):1110–1115

    Article  PubMed  Google Scholar 

  17. Modrzyński M, Zawisza E (2003) Frequency of adenoid hypertrophy in children with allergic diseases. Przegla̧d Sikorski 60:322–324

  18. Modrzyński M, Zawisza E (2007) The analysis of the occurrence of atopic allergy in children with adenoid hypertrophy. Wiad Lek 60:507–512

    PubMed  Google Scholar 

  19. Huang SW, Giannoni C (2001) The risk of adenoid hypertrophy in children with allergic rhinitis. Ann Allergy Asthma Immunol 87:350–355

    Article  CAS  PubMed  Google Scholar 

  20. Costa Junior EC, Sabino HAC, Miura CS, de Azevedo CB, de Menezes UP, Valera FCP et al (2013) Atopy and adenotonsillar hypertrophy in mouth breathers from a reference centre. Braz J Otorhinolaryngol 79(6):663–667

    Article  Google Scholar 

  21. Griffin JL, Ramadan HH, Adham RE (1994) Prevalence of IgE-Mediated hypersensitivity in children with adenotonsillar disease. Arch Otolaryngol Neck Surg 120:150–153

    Article  CAS  Google Scholar 

  22. Atan Sahin O, Kececioglu N, Serdar M, Ozpinar A (2016) The association of residential mould exposure and adenotonsillar hypertrophy in children living in damp environments. Int J Pediatr Otorhinolaryngol. 2016(88):233–238. https://doi.org/10.1016/j.ijporl.2016.07.018

    Article  Google Scholar 

  23. Flint PW, Haughey BH, Lund V et al (2015) Cummings otolaryngology-head and neck surgery, vol. 44

  24. Masieri S, Trabattoni D, Incorvaia C, De Luca MC, Dell’Albani I, Leo G et al (2014) A role for Waldeyer’s ring in the immunological response to allergens. Curr Med Res Opin 30(2):203–205

    Article  CAS  PubMed  Google Scholar 

  25. Shin SY, Ye YM, Eun YG, Kim SW, Cho JS, Park HS (2012) Local IgE-mediated hypersensitivity to Alternaria in pediatric adenoid tissue. Int J Pediatr Otorhinolaryngol 76(10):1423–8. https://doi.org/10.1016/j.ijporl.2012.06.015

    Article  PubMed  Google Scholar 

  26. Shin SY, Choi SJ, Hur GY, Lee KH, Kim SW, Cho JS et al (2009) Local production of total IgE and specific antibodies to the house dust mite in adenoid tissue. Pediatr Allergy Immunol 20:134–141

    Article  PubMed  Google Scholar 

  27. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 320:271–277

    Article  CAS  PubMed  Google Scholar 

  28. Pagella F, De Amici M, Pusateri A, Tinelli G, Matti E, Benazzo M et al (2015) Adenoids and clinical symptoms: epidemiology of a cohort of 795 pediatric patients. Int J Pediatr Otorhinolaryngol 79(12):2137–41. https://doi.org/10.1016/j.ijporl.2015.09.035

    Article  PubMed  Google Scholar 

  29. Singh S, Sharma BB, Salvi S, Chhatwal J, Jain KC, Kumar L et al (2018) Allergic rhinitis, rhinoconjunctivitis, and eczema: prevalence and associated factors in children. Clin Respir J 12:547–556

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of ENT - Head and Neck Surgery, Birat Medical College Teaching Hospital, Tankisinuwari, Biratnagar, Morang, Province 1, Nepal

    Divesh Shah

  2. Department of ENT, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India

    Poorvi V. Sharma & R. Balakrishnan

  3. Department of ENT - Head and Neck Surgery, Manchester Foundation Trust, Manchester, UK

    Shalini Menon

  4. Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India

    Chethana Babu K. Udupa

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  1. Divesh Shah
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  2. Poorvi V. Sharma
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Correspondence to Poorvi V. Sharma.

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Approved from Institutional Ethics committee: IEC622/2018.

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Shah, D., Sharma, P.V., Menon, S. et al. Correlation Between Nasal Allergy and the Number of Eosinophils in Adenoid Tissue. Indian J Otolaryngol Head Neck Surg 76, 871–877 (2024). https://doi.org/10.1007/s12070-023-04300-4

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  • DOI: https://doi.org/10.1007/s12070-023-04300-4

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