Abstract
Head and neck osteosarcoma is an uncommon yet aggressive tumor which presents therapeutic challenges to get favourable results. Surgery remained the most effective treatment modality in this entity eventhough chemoradiotherapy have been tried in various studies for better outcome but still not yet becomes the standard in the management of these cases unlike in extremity osteosarcoma. We present our experience in the management of this uncommon yet lethal malignant tumor, i.e. head and neck osteosarcoma. To study the clinicopathological and prognostic features of Osteosarcoma in head and neck subsite. Retrospective study of patients diagnosed with head and neck osteosarcoma between 2003 and 2019. Total of 25 patients were included in our study. Mean age of our population is 27.5 years with slight male predominant. Mandible is the most commonly involved site. Multimodal treatment applied with surgical resection forms the main part in the management. Median DFS and OS were 16 and 36 months respectively with 5 year overall survival of 42%. Out of the various factors studied, absence of surgery, margin positivity are the principle features affecting the prognosis. Head and neck osteosarcoma is generally a jaw bone tumor commonly occurs in young adults with poor outcome. Since there is no universal guidelines to address this uncommon tumor, multiple studies have shown various results in the management. Till date, surgery remained the curative modality with mixed response on the role of chemotherapy and radiotherapy.
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Conceptualization and methodology—PR. Formal analysis and investigation—KSS, RD, AP, ST. Writing—original draft preparation—KSS. Writing—review and editing—PR, VW, SP. Supervision—SP, SP, MS.
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Sandeep, K.S., Rathod, P., Dalvi, R. et al. Osteosarcoma of Head and Neck Region: Tertiary Cancer Care Center Experience. Indian J Otolaryngol Head Neck Surg 76, 581–586 (2024). https://doi.org/10.1007/s12070-023-04216-z
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DOI: https://doi.org/10.1007/s12070-023-04216-z