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Oral Manifestation of Viral-Induced Erythema Multiforme Major: A Rare Presentation

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Erythema multiforme is an acute inflammatory mucocutaneous disease manifested as macules, vesicles, bullae, erosion, and papular lesions. In the present case, a 55-year-old female patient reported painful growth in the oral cavity and difficulty in mastication. The patient gave a history of prodromal symptoms before the onset of lesions On intra-oral examination, elevated plaque-like lesions were present bilaterally on lateral borders of the tongue and buccal mucosa near the retromolar region. Extraoral examination revealed concentric erythematous target (or) bull’s eye lesions in palms, forearm, and foot. Based on history, clinical examination, and laboratory investigations, recurrent herpes-associated erythema multiforme was diagnosed. We report a rare clinical presentation of recurrent herpes-associated erythema multiforme manifesting as an extensive plaque-like lesion intra-orally.

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Abbreviations

EM:

Erythema Multiforme

HSV:

Herpes Simplex Virus

ESR:

Erythrocyte Sedimentation Rate

HAEM:

Herpes-associated erythema multiforme

HSV DNA:

Herpes Simplex Virus Double-Stranded DNA

IFN-i γ/α:

Interferon-γ/α

M. pneumonia:

Mycoplasma Pneumonia

JAK-inhibitors:

Janus kinase inhibitors

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Funding

This research did not receive any specific grant from the funding agencies in the public, commercial, or not for profit sectors.

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Authors and Affiliations

  1. Government Dental College and Hospital, Chennai, Tamil Nadu, India

    T Jeyanthikumari

  2. Private Practitioner, Chennai, Tamil Nadu, India

    B Thayumanavan

  3. Department of Oral Pathology and Microbiology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, India

    Khadijah Mohideen

  4. Tamilnadu Government Dental College, Chennai, India

    S Vinayakam

  5. Department of Oral Pathology, College of Medical Sciences, Bharatpur, Nepal

    Snehashish Ghosh

  6. Department of Oral and Maxillofacial Surgery, College of Medical Sciences, Bharatpur, Nepal

    Safal Dhungel

Authors
  1. T Jeyanthikumari
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  2. B Thayumanavan
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  3. Khadijah Mohideen
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  4. S Vinayakam
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  5. Snehashish Ghosh
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  6. Safal Dhungel
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Contributions

KM, JT, TB, and SG prepared the manuscript, SD, SG and JT did the literature review, MP and SD critically reviewed the manuscript. All authors have reviewed and approved the final draft and are responsible for the content and similarity index of the manuscript.

Corresponding author

Correspondence to Snehashish Ghosh.

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Not applicable since there is no ethical issue.

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was obtained from the above-described patient regarding the use of any clinical, radiographical, and other diagnostic and histopathological data or photographs for academic or publication purposes.

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Jeyanthikumari, T., Thayumanavan, B., Mohideen, K. et al. Oral Manifestation of Viral-Induced Erythema Multiforme Major: A Rare Presentation. Indian J Otolaryngol Head Neck Surg 76, 1164–1167 (2024). https://doi.org/10.1007/s12070-023-04195-1

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  • DOI: https://doi.org/10.1007/s12070-023-04195-1

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