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Laryngeal EBV-positive Inflammatory Follicular Dendritic cell/fibroblastic Reticular cell Tumour

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Epstein-Barr virus-positive Inflammatory follicular dendritic cell/fibroblastic reticular cell tumour (EBV-IFDC/FRCT) is a rare neoplasm that occurs almost exclusively in the liver or spleen. Extra-hepatosplenic presentation is infrequent and exceptional cases have been described arising in the gastrointestinal tract or in the pharynx. However, EBV-IFDC/FRCT cases have not been previously reported in the larynx.

This report describes a case of a 32-year-old woman who arrived to the emergency department due to progressive dyspnea with associated inspiratory stridor and non-productive cough. Direct laryngoscopy showed a nodular tumour arising on the left posterior subglottic mucosa obstructing 90% of the airway. A preoperative dual energy contrast enhanced computed tomography (CECT) was performed demonstrating a low attenuation lesion on virtual non-contrast (VNC) images and vivid iodine uptake on the iodine map. The tumour was excised and the histopathological analysis led to the diagnosis of an EBV-IFDC/FRCT. A fibre-optic laryngoscopy six months after the surgery did not show any abnormalities.

Although the vast majority of EBV-IFDC/FRCT occur in the liver or spleen, some extra hepatosplenic tumours have been reported affecting the head and neck region. We describe here the first case arising in the larynx, as well as the usefulness of preoperative dual energy imaging techniques to assess these lesions, thus providing information that could have management implications.

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Abbreviations

EBV-IFDC/FRCT:

Epstein-Barr virus-positive Inflammatory follicular dendritic cell/fibroblastic reticular cell tumour

CECT:

Contrast enhanced Computed Tomography

VNC:

Virtual non-contrast

HU:

Hounsfield unit

FDCS:

Follicular dendritic cell sarcomas

SMA:

Smooth muscle actin

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Funding

No funding was received to assist with the preparation of this manuscript.

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Author notes

  1. Alex Gil and Natalia Castrejon-de-Anta contributed equally to the study.

Authors and Affiliations

  1. Radiology Department of Hospital Clínic Barcelona, Barcelona, Spain

    Alex Gil & Laura Oleaga

  2. Pathology Department of Hospital Clínic Barcelona, Villarroel 170, Barcelona, 08036, Spain

    Natalia Castrejon-de-Anta, Gerard Frigola & Elias Campo

  3. Functional Unit of Head Neck Tumors. Hospital Clínic Barcelona, Barcelona, Spain

    Isabel Vilaseca

  4. Department of Surgery. School of Medicine. University of Barcelona, Barcelona, Spain

    Isabel Vilaseca

Authors
  1. Alex Gil
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  2. Natalia Castrejon-de-Anta
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  3. Isabel Vilaseca
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  4. Gerard Frigola
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  5. Elias Campo
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  6. Laura Oleaga
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Contributions

All authors contributed to the study conception and design. Isabel Vilaseca examined the patient, performed the fibre-laryngoscopy and the resection of the lesion. Laura Oleaga and Alex Gil interpreted the imaging data. Natalia Castrejon de Anta, Gerard Frigola and Elias Campo performed the histological examination. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Natalia Castrejon-de-Anta.

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Competing Interests

The authors have no relevant financial or non-financial interests to disclose.

Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki.

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Gil, A., Castrejon-de-Anta, N., Vilaseca, I. et al. Laryngeal EBV-positive Inflammatory Follicular Dendritic cell/fibroblastic Reticular cell Tumour. Indian J Otolaryngol Head Neck Surg 75, 3941–3944 (2023). https://doi.org/10.1007/s12070-023-03937-5

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  • DOI: https://doi.org/10.1007/s12070-023-03937-5

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