Abstract
Objectives
Total Thyroidectomy (TT) in true sense is not total as evidenced by remnant uptake in radio-iodine scans and serum thyroglobulin. The aim of this study is to assess the completeness of TT, operating time and recurrent laryngeal nerve injury with and without neuro-monitoring (IONM).
Methods
Cross sectional analytical study using retrospective data of patients undergoing total thyroidectomy for benign and malignant goiters. Surgeries performed by single surgeon. Patients undergoing TT (2015-22) were grouped into Group A (n = 400) and Group B (n = 400) based on use of IONM. Subgroup of patients (Group A1&B1) who had differentiated thyroid cancer were compared for completeness of thyroidectomy with DxWBS and serum thyroglobulin (TG). Group A and B were compared for operating time and incidence of RLN palsy.
Results
Of the 800 RLN at risk transient RLN palsy was lower with IONM (p = 0.048). Mean operating time was significantly higher in Group-B(p = 0.0038). Subgroup A1 showed lower radio-active iodine uptake percentage, higher number of patients with negative scan, TG of < 1ng/mL indicating better completeness of TT.
Conclusion
Our study shows better completeness of thyroidectomy, lower incidence of transient RLN palsy and shorter operating time with IONM.
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References
Salvatori M, Raffaelli M, Castaldi P et al (2007) Evaluation of surgical completeness after total thyroidectomy for differentiated thyroid cancer. EJSO. https://doi.org/10.1016/j.ejso.2007.02.034
Pradeep PV, Jayashree B, Harshita SS (2012) A closer look at laryngeal nerves during thyroid surgery: a descriptive study of 584 nerves. Anatomy Research International. ;2012. https://doi.org/10.1155/2012/490390
Pradeep PV (2014) A closer look at parathyroid anatomy during thyroid surgery. BMH Med Journal-ISSN 2348–392X 1(4):66–71
Veetil PP, Panchangam RB Does goitre size and delayed surgical intervention adversely affect surgical outcome? A multi-centric experience on thyroidectomy. Formosan Journal of Surgery. 2021 Nov 1;54(6):219 – 25. DOI:https://doi.org/10.4103/fjs.fjs_223_20
Lo C, Kwok F, Yuen P (2000) A prospective evaluation of recurrent laryngeal nerve paralysis during Thyroidectomy. Arch Surg 135:204–207. https://doi.org/10.1001/archsurg.135.2.204
Randolph GW, Dralle H (2011) Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: international standards guideline statement. Laryngoscope 121:S1–S6. https://doi.org/10.1002/lary.21119
Barczyński M, Konturek A, Cichoń S (2009 Mar) Randomized clinical trial of visualization versus neuromonitoring of recurrent laryngeal nerves during thyroidectomy. J Br Surg 96(3):240–246. https://doi.org/10.1002/bjs.6417
Demiryas S, Donmez T, Cekic E (2018) Effects of nerve monitoring on complication of thyroid surgery. North Clin Istanb 5:14–19. https://doi.org/10.14744/nci.2017.93764
Lin HS, Terris DJ (2017) An update on the status of nerve monitoring for thyrpoid parathyroidsurgery.CurrOpinOncol. 29:14–19. https://doi.org/10.1097/CCO.0000000000000334
Pisanu A, PorcedduG, Podda M et al (2014) Systematic review with meta-analysis of studies comparing intra operative neuromonitoring of recurrent laryngeal nerves versus visualization alone during thyroidectomy. J Surg Res 188:152–161. https://doi.org/10.1016/j.jss.2013.12.022
Yang S, Zhou L, Lu Z et al (2017) Systematic review with meta-analysis of intraoperative neuromonitoring during thyroidectomy. Int J Surg 39:104–113. https://doi.org/10.1016/j.ijsu.2017.01.086
Sari S, Erbil Y, Sumer A et al (2010) Evaluation of recurrent laryngeal nerve monitoring in thyroid surgery. Int J Surg 8:474–478. https://doi.org/10.1016/j.ijsu.2010.06.009
Polachek A, Hirsch D, Tzvetov G, Grozinsky-Glasberg S, Slutski I, Singer J, Weinstein R, Shimon I, Benbassat CA (2011 Dec) Prognostic value of post-thyroidectomy thyroglobulin levels in patients with differentiated thyroid cancer. J Endocrinol Investig 34:855–860. https://doi.org/10.3275/7768
Kim TY, Kim WB, Kim ES et al (2005) Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low risk patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 90:1440–1445. https://doi.org/10.1210/jc.2004-1771
Isabela deO, Amui, Tagliarini JV, Castilho EC et al (2019) The first postoperative-stimulated serum thyroglobulin is a prognostic factor for thyroid microcarcinomas. Braz J Otorhinolaryngol 2019;85:37–42. https://doi.org/10.1016/j.bjorl.2017.10.005
Fratkin MJ, Newsome HH, Sharpe AR, Tatum JL Cervical distribution of iodine 131 following total thyroidectomy for thyroid cancer. Archives of Surgery. 1983 Jul 1;118(7):864-7. DOI: https://doi.org/10.1001/archsurg.1983.01390070072014
Randolph DW, Daniels GH (2002) Radioactive iodine lobe ablation as an alternative to completion thyroidectomy for follicular carcinoma of thyroid. Thyroid 12:989–996. https://doi.org/10.1089/105072502320908321
Salvatori M, Raffaelli M, Castaldi P (2007) Evaluation of surgical completeness after total thyroidectomy for differentiated thyroid carcinoma. Eur J Surg Oncol 33:648–654. https://doi.org/10.1016/j.ejso.2007.02.034
Gurleyik E, Dogan S (2014) Accuracy of unstimulated basal serum thyroglobulin levels in assessing the completeness of thyroidectomy. J Clin Med Res 6(5):369–373. https://doi.org/10.14740/jocmr1873w
Acknowledgements
Authors wish to acknowledge the contributions of Dr Maharajan MD of Nuclear Medicine Department, Mr Selvaraj from the Dept of Laboratory Medicine.
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Author 1 (PPV) designed the model and the computational framework and analyzed the data. Author 2 (SP)carried out the implementation. Author 1 performed the calculations. Author 1 and 2 wrote the manuscript. Author 1 and 2 conceived the study and were in charge of overall direction and planning.
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Veetil, P.P., Puzhakkal, S. A Comparison of Completeness and Complication of Total Thyroidectomy with or Without Neuromonitoring. Indian J Otolaryngol Head Neck Surg 75, 1647–1650 (2023). https://doi.org/10.1007/s12070-023-03686-5
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DOI: https://doi.org/10.1007/s12070-023-03686-5