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Association of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio with Persistent Allergic Rhinitis

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Allergic rhinitis is a disease that affects approximately 15–25% of the World population. It is characterized by itching, sneezing, and nasal or postnasal drip. Generally, diagnosis is based on clinical findings and patient history. Laboratory tests that can be used in the diagnosis and clinical course of AR are still limited and should be improved. Neutrophil-lymphocyte ratio (NLR) and Platelet Lymphocyte Ration(PLR) are novel markers for the evaluation of inflammation. This study aims to investigate whether NLR and PLR, would be useful in diagnosis and monitoring the severity of disease in allergic rhinitis. It is a 1 year cross sectional study which assesses 140 patients, 70 belonging each to case and control group. NLR and PLR ratio was measured and compared in case and control groups. Mean NLR was 1.92 in patient group and in control group it was 1.54 (P value < 0.001). Mean PLR was 1.33 in patient group and in control group it was 0.88 (p < 0.001). Mean NLR in mild cases was 1.68 and in moderate to severe cases was 2.15 (p value 0.002). Mean PLR was 1.49 in moderate to severe disease and in mild disease it was 1.18 (p value 0.006). To conclude NLR and PLR were significantly higher in moderate to severe allergic rhinitis and not so in mild cases. Hence in allergic rhinitis NLR and PLR can be used as a marker of severity of disease according to symptoms of the disease.

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References

  1. RovaiD SbranaF,CocciF,PapaA,LandiP,L’AbbateA,RossiG. Neutrophil-to-lymphocyte ratio predicts prognosis in patients with chronic Coronary Heart Disease

  2. Wu Y, Chen Y, Yang X, Chen L, Yang Y (2016) Neutrophil-to- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. International immunopharmacology. Jul 1;36:94 – 9

  3. Dogru M, Evcimik MF, Cirik AA (2016 Oct) Is neutrophil–lymphocyte ratio associated with the severity of allergic rhinitis in children?. European archives of Oto-Rhino-Laryngology. 273:3175–317810

  4. Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S (2012 Dec) Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in asian population. Int archives Med 5(1):1–6

  5. Bosquet J, van Cayuwerberge P, Kholtaev N Allergic rhinitis and its impact on asthma (ARIA). Pocket Guide-WHO.–2001. 2001;23

  6. Sagmen SB, Kıral N (2020) The evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in asthma control. Revue Française d’Allergologie. Feb 1;60(1):20 – 3

  7. Smurthwaite L, Walker SN, Wilson DR, Birch DS, Merrett TG, Durham SR, Gould HJ (2001 Dec) Persistent IgE synthesis in the nasal mucosa of hay fever patients. Eur J Immunol 31(12):3422–3431

  8. ScalabrinDM,BavbekS,PerzanowskiMS,WilsonBB,Platts-Mills TA, Wheatley LM (1999) Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. Journal of allergy and clinical immunology. Dec 1;104(6):1273-9

  9. Wilson DR, Merrett TG, Varga EM, Smurthwaite L (2002) Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics. American journal of respiratory and critical care medicine. Jan 1;165(1):22 – 6

  10. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, Meghani M, Akhtar M, Costantino T Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert review of cardiovascular therapy. 2013 Jan 1;11(1):55 – 9

  11. RovaiD SbranaF,CocciF,PapaA,LandiP,L’AbbateA,RossiG. Neutrophil-to-lymphocyte ratio predicts prognosis in patients with chronic Coronary Heart Disease

  12. Gao Y, Wang WJ, Zhi Q, Shen M Neutrophil/lymphocyte ratio is a more sensitive systemic inflammatory response biomarker than platelet/lymphocyte ratio in the prognosis evaluation of unresectable pancreatic cancer.Oncotarget. 2017 Oct24;8(51):88835

  13. Templeton AJ, McNamara MG, Šeruga B, Vera-Badillo FE, Aneja P, Ocaña A, Leibowitz-Amit R, Sonpavde G, Knox JJ, Tran B, Tannock IF (2014) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. JNCI: Journal of the National Cancer Institute. Jun 1;106(6)

  14. McNamara MG, Templeton AJ, Maganti M, Walter T, Horgan AM, McKeever L, Min T, Amir E, Knox JJ Neutrophil/lymphocyte ratio as a prognostic factor in biliary tract cancer. European Journal of Cancer. 2014 Jun 1;50(9):1581-9

  15. Diem S, Schmid S, Krapf M, Flatz L, Born D, Jochum W, Templeton AJ, Früh M (2017) Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab. Lung cancer. Sep 1;111:176 – 81

  16. DogruM,MutluRY. Theevaluationofneutrophil–lymphocyteratio in children with asthma. Allergologia et immunopathologia. 2016 Jul 1;44(4):292-6

  17. Gelardi M, Incorvaia C, Passalacqua G The classification of allergic rhinitis and its cytological correlate. Allergy. 2011 Dec 1;66(12):1624-5

  18. Atan D, İkincioğulları A, Köseoğlu S, Özcan KM, Çetin MA, Ensari S, Dere H (2015 Apr) New Predictive Parameters of Bell’s Palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan Med J 32(2):167–170. https://doi.org/10.5152/balkanmedj.2015.15456Epub 2015 Apr 1. PMID: 26167340; PMCID: PMC4432696

  19. Alan S, Tuna S, Türkoğlu EB The relation of neutrophil-to- lymphocyte ratio,platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet’s syndrome. The Kaohsiung journal of medical sciences.2015 Dec 1;31(12):626 – 31

  20. Uslu AU, Küçük A, Şahin et al (2015 Sep) Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio. Int J Rheum Dis 18(7):731–735

  21. Göker AE, Ekincioglu E, Alagöz MH, Hummatov R, Arkan ME, Yilmazer AB, Doğuşlu AG, Uyar Y (2019 Dec) The association of allergic rhinitis severity with neutrophil–lymphocyte and platelet– lymphocyte ratio in adults. European archives of Oto-Rhino- Laryngology. 276:3383–338812

  22. Wu Y, Chen Y, Yang X, Chen L, Yang Y (2016) Neutrophil-to- lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. International immunopharmacology. Jul 1;36:94 – 9

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  1. Dept of ENT, SMS Medical college, Jaipur, Rajasthan, India

    Vikas Rohila, Siddharth Nirwan, Sunil Samdhani, Samanvaya Soni & Pawan Kumar Sharma

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  1. Vikas Rohila
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  2. Siddharth Nirwan
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  3. Sunil Samdhani
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  4. Samanvaya Soni
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Correspondence to Samanvaya Soni.

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Rohila, V., Nirwan, S., Samdhani, S. et al. Association of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio with Persistent Allergic Rhinitis. Indian J Otolaryngol Head Neck Surg 75, 2842–2846 (2023). https://doi.org/10.1007/s12070-023-03557-z

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