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Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucosal fibrosis (OSMF) and squamous cell carcinoma (OSCC). Serum was isolated from, peripheral blood collected of clinically and histopathologically confirmed OSMF and OSCC patients. Circulating level of survivin was measured in patients and control subjects by ELISA and analyzed further using Kruskal–Wallis test and two-sample Wilcoxon rank-sum (Mann–Whitney) test. Serum Survivin levels were significantly reduced in the OSCC group as compared to the control group. No significant correlation was noted between the serum survivin level and various clinicopathological characteristics of OSCC and OSMF patients. Our study suggests that free, wild form of circulating survivin probably has no role in predicting the prognosis of oral cancer or the malignant transformation potential of oral submucosal fibrosis.

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Authors and Affiliations

  1. Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Sadhna Aggarwal & Satya N. Das

  2. Department of Otorhinolaryngology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Ramya Thota, Amit Singh Chirom, Alok Thakar & Suresh C. Sharma

  3. Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India

    Siddhartha Dutta Gupta

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  1. Ramya Thota
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  2. Sadhna Aggarwal
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  3. Amit Singh Chirom
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  4. Alok Thakar
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  5. Siddhartha Dutta Gupta
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  6. Suresh C. Sharma
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  7. Satya N. Das
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Correspondence to Satya N. Das.

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The study was approved by the ‘Ethics Committee’ of All India Institute of Medical Sciences and Informed consent was obtained from all participants.

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Thota, R., Aggarwal, S., Chirom, A.S. et al. Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 2027–2032 (2022). https://doi.org/10.1007/s12070-020-01980-0

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  • DOI: https://doi.org/10.1007/s12070-020-01980-0

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