Abstract
To evaluate treatment response in patients with laryngopharyngeal reflux (LPR). A prospective study of 100 patients with voice disorders was conducted. Patients were evaluated using reflux symptom index (RSI) and reflux finding score (RFS) by 70° rigid laryngoscope. Patients with RFS score of 7 or more were diagnosed of having LPR and were started with anti-reflux therapy for a period of 6 months. Patients were assessed at regular intervals using RSI and RFS. The prevalence of LPR in patients with voice disorders was found to be 25%. The mean RSI score improved gradually and significantly over a period of 6 months from 11.84 at presentation to 2.04 after 6 months of treatment (p value <0.001). The mean value of RFS improved from 7.92 at entry to 1.52 after 6 months of treatment (p value <0.001). However, it was found that the improvement was not significant at end of first month of treatment, and improvement in RSI and RFS scores was found only after 2 months of treatment. RSI and RFS improve significantly after treatment for 6 months with PPI like Omeprazole. But the improvement starts from the 2nd month from the onset of treatment. Treatment of LPR for at least 6 months may be indicated to attain a full resolution of physical findings.
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References
Vaezi MF (2003) Extraesophageal manifestations of gastroesophageal reflux disease. Clin Cornerstone 5:32–38
Park W, Hicks DM, Khandwala F et al (2005) Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. Laryngoscope 115:1230–1238
Belafsky PC, Postma GN, Koufman JA (2001) The validity and reliability of the reflux finding score (RFS). Laryngoscope 111(8):1313–1317
Katz PO, Castell DO (2000) Medical therapy of supra- esophageal gastroesophageal reflux disease. Am J Med 108(suppl 4a):170S–177S
Steward DL, Wilson KM, Kelly DH et al (2004) Proton pump inhibitor therapy for chronic laryngopharyngitis: a randomized placebo-control trial. Otolaryngol Head Neck Surg 131:342–350
Habermann W, Schmid C, Neumann K, Devaney T, Hammer HF (2012) Reflux symptom index and reflux finding score in otolaryngologic practice. J Voice 26(3):e123–e127
Rouev P, Chakarski I, Doskov D, Dimov G, Staykova E (2005) Laryngopharyngeal symptoms and gastroesophageal reflux disease. J Voice 19(3):476–480
Belafsky PC, Postma GN, Koufman JA (2001) Laryngopharyngeal reflux symptoms improve before changes in physical findings. Laryngoscope 111(6):979–981
Koufman J, Sataloff RT, Toohill R (1996) Laryngopharyngeal reflux: consensus conference report. J Voice 10(3):215–216
Noordzij JP, Khidr A, Evans BA, Desper E, Mittal RK, Reibel JF et al (2001) Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study. Laryngoscope 111(12):2147–2151
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Joshi, A.A., Chiplunkar, B.G. & Bradoo, R.A. Assessment of treatment response in patients with laryngopharyngeal reflux. Indian J Otolaryngol Head Neck Surg 69, 77–80 (2017). https://doi.org/10.1007/s12070-016-1046-5
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DOI: https://doi.org/10.1007/s12070-016-1046-5