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KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

To study the clinical presentation and review the options in the management of laryngeal amyloidosis. To study the efficacy of KTP 532 laser in the excision of laryngeal amyloidosis. Study was conducted in our department in a tertiary care hospital between Jan 2001 and Feb 2010. We report five patients who presented with hoarseness of voice and localized laryngeal lesions. The biopsy proven laryngeal amyloidosis lesions were excised microendoscopically using KTP 532 laser in three patients and other two patients were kept only on follow-up as they refused further surgery. The patients were evaluated for systemic amyloidosis. The average duration of follow up was 2.6 years (3 months 6 years). All the five patients in our study were asymptomatic with no evidence of recurrence at their last follow up. In our small case series, KTP 532 laser excision of the laryngeal amyloidosis had a favorable outcome. Long term follow up is required to rule out recurrence and systemic involvement.

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References

  1. Kyle RA, Bayrd ED (1975) Amyloidosis: review of 236 cases. Medicine 54:271–299

    Article  PubMed  CAS  Google Scholar 

  2. Walter JB, Israel MS (1987): Amyloidosis (β-fibrillosis). In: General pathology, 6th edn. London, Churchill Livingstone, 606-612

  3. Tsai YT, Huang CM, Chen YJ, Leu YS (2005) Localized nasopharyngeal amyloidosis- a case report. Tzu chi Med J 17(5):353–355

    Google Scholar 

  4. Alaani A, Warfield AT, Pracy JP (2004) Management of laryngeal amyloidosis. J Laryngol Otol 118:279–283

    PubMed  CAS  Google Scholar 

  5. Kennedy TL, Patel NM (2000) Surgical management of localized amyloidosis. Laryngoscope 110(6):918–923

    Article  PubMed  CAS  Google Scholar 

  6. Lewis JE, Olsen KD, Kurtin PJ, Kyle RA (1992) Laryngeal amyloidosis: a clinicopathologic, immunohistochemical review. Otolaryngol Head Neck Surg 106:372–377

    PubMed  CAS  Google Scholar 

  7. Theberge R, Connors L, Skinner M, Skare J, Costello CE (1999) Characterization of transthyretin mutants from serum using immunoprecipitation, electrospray ionization and matrix assisted laser desorption/ionization mass spectrometry. Ann Chem 71(2):452–459

    Article  CAS  Google Scholar 

  8. Galvan OG, Teran LA, Fernandez J, Pasquel P (1989) Beta-2 microglobulin as the main component of primary amyloidosis located in the larynx. Laryngoscope 99:1072–1074

    Google Scholar 

  9. Gean-Marton AD, Kirsch CF, Vezina LG, Weber AL (1991) Focal amyloidosis of the head and neck: evaluation with CT and MRImaging. Radiology 181:521–525

    PubMed  CAS  Google Scholar 

  10. Kyle RA, Greipp PR (1983) Amyloidosis. Mayo Clin Proc 58:665–683

    PubMed  CAS  Google Scholar 

  11. Glenner GG (1980) Amyloid deposits and amyloidosis. N Engl J Med 302(1283–1292):1333–1343

    Article  PubMed  CAS  Google Scholar 

  12. Barnes EL, Zafar T (1977) Laryngeal amyloidosis: clinicopathologic study of seven cases. Ann Otol Rhinol Laryngol 86(6):856–863

    PubMed  Google Scholar 

  13. Mittrani M, Biller HF (1985) Laryngeal amyloidosis. Laryngoscope 95:1346–1347

    Google Scholar 

  14. Finn DG, Farmer JC (1982) Management of amyloidosis of the larynx and trachea. Arch otolaryngol 108:54–56

    Article  PubMed  CAS  Google Scholar 

  15. Graamans K, Lubsen H (1985) Clinical implications of laryngeal amyloidosis. J Laryngol Otol 99:617–623

    Article  PubMed  CAS  Google Scholar 

  16. Naraghi M, Kazemi M (2006) Hoarseness as presenting symptom of pediatric laryngeal amyloidosis. Acta Medica Iranica 44(4):277–280

    Google Scholar 

  17. Tsai TL, Chu PY, Chang SY (2002) Laryngeal amyloidosis with airway obstruction. Otolaryngol Head Neck Surg 126(3):329–330

    Article  PubMed  Google Scholar 

  18. Prabitkin E, Friedman O, O’Hara B, Cunnane MF, Levi D, Rosen M et al (2003) Amyloidosis of upper aerodigestive tract. Laryngoscope 113(12):2095–2101

    Article  Google Scholar 

  19. Behranwala KA, Asgar AB, Borges A, Marfatia PT (2004) Laser in treatment of laryngeal amyloidosis. Indian J Otolaryngol Head Neck Surg 56(1):46–48

    PubMed  Google Scholar 

  20. Ergas D, Abramowitz Y, Lahav Y, Halpenrin D, Sthoeger ZM (2006) Exertion dyspnea and stridor: an unusual presentation of localized laryngeal amyloidosis. Israel Medical Assoc J 8:73–74

    Google Scholar 

  21. Dabholkar JP, More M, Avanindra K, Sharma A (2007) Primary exophytic amyloidosis presenting as sudden airway obstruction. Indian J Otolaryngol Head Neck Surg 59(4):357–359

    Article  PubMed  Google Scholar 

  22. Ramos Meca MA, Martin MZ, Esteban JJ, Fernandez FV, Menchero SC, Sanchez LC (1999) Localized tracheobroncheal amyloidosis: a case report, review of the literature. An Med Interna 16(6):297–298

    PubMed  CAS  Google Scholar 

  23. Romero RR, Serrano BV, Moreno BC, Gallardo JMF, Rodilla JLC (1996) Calcified amyloidoma of the larynx. Am J Neuroradiol 17:1491–1493

    Google Scholar 

  24. Nandapalan V, Jones TM, Morar P, Clark AH, Jones AS (1998) Localized amyloidosis of parotid gland: a case report, review of the localized amyloidosis of the head, neck. Head Neck 20(1):73–78

    Article  PubMed  CAS  Google Scholar 

  25. Arslan A, ceylan N, Cetin A, Demirci A (1998) Laryngeal amyloidosis with laryngocele: MRI, CT. Neuroradiology 40(6):401–403

    Article  PubMed  CAS  Google Scholar 

  26. Hegarty JL, Rao VM (1993) Amyloidoma of the nasopharynx: CT and MR findings. Am J Neuroradiol 14:215–218

    PubMed  CAS  Google Scholar 

  27. Godbersen GS, Leh JF, Hansmann ML, Rudert H, Linke RP (1992) Organ-limited laryngeal amyloid deposits: clinical, morphological and immunohistochemical results of five cases. Ann Otol Rhinol Laryngol 101:770–775

    PubMed  CAS  Google Scholar 

  28. Mishell JH, Schild JA, Mafee MF (1990) Chondrosarcoma of the larynx: diagnosis with magnetic resonance imaging and computed tomography. Arch Otolaryngol Head Neck Surg 116:1338–1341

    Article  PubMed  CAS  Google Scholar 

  29. Aspestrand F, Kolbenstvedt A, Boysen M (1989) CT findings in benign expansions of the larynx. J Comput Assist Tomogr 13:222–225

    Article  PubMed  CAS  Google Scholar 

  30. Pepys MB, Herbert J, Hutchison WL, Tennent GA, Lachmann HJ, Gallimore JR et al (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature 417(6886):254–259

    Article  PubMed  CAS  Google Scholar 

  31. Hellquist H, Olofsson J, Sokjer H, Odkvist LM (1979) Amyloidosis of the larynx. Acta Otolaryngol 88:443–450

    Article  PubMed  CAS  Google Scholar 

  32. Thompson LD, Derringer GA, Wenig BM (2000) Amyloidosis of the larynx: a clinicopathologic study of 11 cases. Mod Pathol 13(5):528–535

    Article  PubMed  CAS  Google Scholar 

  33. Antuna SA, Marron MG, Garcia JM, Martinez MA, Rodriguez SA, Blanco BI (1995) Localized tracheobroncheal amyloidosis, the usefulness of computed tomography. Arch Bronconeumol 31:540–542

    Google Scholar 

  34. Utz JP, Swensen SJ, Gertz MA (1996) Pulmonary amyloidosis. The Mayo Clinic experience from 1980 to 1993. Ann Intern Med 124(4):407–413

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck surgery, Kasturba Medical College, Manipal University, Manipal, 576104, India

    D. Deviprasad, K. Pujary, R. Balakrishnan & D. R. Nayak

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  1. D. Deviprasad
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  2. K. Pujary
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  3. R. Balakrishnan
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  4. D. R. Nayak
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Correspondence to K. Pujary.

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Deviprasad, D., Pujary, K., Balakrishnan, R. et al. KTP Laser in Laryngeal Amyloidosis: Five Cases with Review of Literature. Indian J Otolaryngol Head Neck Surg 65 (Suppl 1), 36–41 (2013). https://doi.org/10.1007/s12070-011-0435-z

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  • DOI: https://doi.org/10.1007/s12070-011-0435-z

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