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Adipokine leptin in obesity-related pathology of breast cancer

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References

  • Artac M and Altundag K 2011 Leptin and breast cancer: an overview. Med. Oncol. doi:10.1007/s12032-011-0056-0

  • Babaei A, Zarkesh-Esfahani SH, Bahrami E and Ross RJ 2011 Restricted leptin antagonism as a therapeutic approach to treatment of autoimmune diseases. Hormones (Athens) 10 16–26

    Google Scholar 

  • Banks WA, Gertler A, Solomon G, Niv-Spector L, Shpilman M, Yi X, Batrakova E, Vinogradov S, et al. 2011 Principles of strategic drug delivery to the brain (SDDB): development of anorectic and orexigenic analogs of leptin. Physiol. Behav. 105 145–149

    Article  PubMed  CAS  Google Scholar 

  • Carroll PA, Healy L, Lysaght J, Boyle T, Reynolds JV, Kennedy MJ, Pidgeon G and Connolly EM 2011 Influence of the metabolic syndrome on leptin and leptin receptor in breast cancer. Mol. Carcinog. 50 643–651

    Article  PubMed  CAS  Google Scholar 

  • Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY, Chen HY, Hou MF, et al. 2006 Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett. 237 109–114

    Article  PubMed  CAS  Google Scholar 

  • Cirillo D, Rachiglio AM, la Montagna R, Giordano A and Normanno N 2008 Leptin signaling in breast cancer: an overview. J. Cell. Biochem. 105 956–964

    Article  PubMed  CAS  Google Scholar 

  • Cleary MP, Grossmann ME and Ray A 2010 Effect of obesity on breast cancer development. Vet. Pathol. 47 202–213

    Article  PubMed  CAS  Google Scholar 

  • Cleary MP, Ray A, Rogozina OP, Dogan S and Grossmann ME 2009 Targeting the adiponectin:leptin ratio for postmenopausal breast cancer prevention. Front. Biosci. S1 329–357

    CAS  Google Scholar 

  • Doyle SL, Donohoe CL, Lysaght J and Reynolds JV 2012 Visceral obesity, metabolic syndrome, insulin resistance and cancer. Proc. Nutr. Soc. 71 181–189

    Article  PubMed  CAS  Google Scholar 

  • Frankenberry KA, Skinner H, Somasundar P, McFadden DW and Vona-Davis LC 2006 Leptin receptor expression and cell signaling in breast cancer. Int. J. Oncol. 28 985–993

    PubMed  CAS  Google Scholar 

  • Friedenreich CM, Neilson HK, Woolcott CG, McTiernan A, Wang Q, Ballard-Barbash R, Jones CA, Stanczyk FZ, et al. 2011 Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women. Endocr. Relat. Cancer 18 357–369

    Article  PubMed  CAS  Google Scholar 

  • Garofalo C, Koda M, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S, et al. 2006 Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin. Cancer Res. 12 1447–1453

    Article  PubMed  CAS  Google Scholar 

  • Goodwin PJ, Ennis M, Pritchard KI, Trudeau ME, Koo J, Taylor SK and Hood N 2012 Insulin- and obesity-related variables in early-stage breast cancer: correlations and time course of prognostic associations. J. Clin. Oncol. 30 164–171

    Article  PubMed  Google Scholar 

  • Grossmann ME, Nkhata KJ, Mizuno NK, Ray A and Cleary MP 2008a Effects of adiponectin on breast cancer cell growth and signaling. Br. J. Cancer 98 370–379

    Article  PubMed  CAS  Google Scholar 

  • Grossmann ME, Ray A, Dogan S, Mizuno NK and Cleary MP 2008b Balance of adiponectin and leptin modulates breast cancer cell growth. Cell Res. 18 1154–1156

    Article  PubMed  CAS  Google Scholar 

  • Grossmann ME, Ray A, Nkhata KJ, Malakhov DA, Rogozina OP, Dogan S and Cleary MP 2010 Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer Metastasis Rev. 29 641–653

    Article  PubMed  CAS  Google Scholar 

  • Guo S and Gonzalez-Perez RR 2011 Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer. PLoS One 6 e21467

    Article  PubMed  CAS  Google Scholar 

  • Hancke K, Grubeck D, Hauser N, Kreienberg R and Weiss JM 2010 Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res. Treat. 119 367–377

    Article  PubMed  CAS  Google Scholar 

  • Iikuni N, Lam QL, Lu L, Matarese G and La Cava A 2008 Leptin and Inflammation. Curr. Immunol. Rev. 4 70–79

    Article  PubMed  CAS  Google Scholar 

  • Ishikawa M, Kitayama J and Nagawa H 2004 Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin. Cancer Res. 10 4325–4331

    Article  PubMed  CAS  Google Scholar 

  • Jardé T, Caldefie-Chézet F, Damez M, Mishellany F, Penault-Llorca F, Guillot J and Vasson MP 2008 Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol. Rep. 19 905–911

    PubMed  Google Scholar 

  • Jardé T, Perrier S, Vasson MP and Caldefie-Chézet F 2011 Molecular mechanisms of leptin and adiponectin in breast cancer. Eur. J. Cancer 47 33–43

    Article  PubMed  Google Scholar 

  • Jeong YJ, Bong JG, Park SH, Choi JH and Oh HK 2011 Expression of leptin, leptin receptor, adiponectin, and adiponectin receptor in ductal carcinoma in situ and invasive breast cancer. J. Breast Cancer 14 96–103

    Article  PubMed  Google Scholar 

  • Koda M, Kanczuga-Koda L, Sulkowska M, Surmacz E and Sulkowski S 2010 Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy. BMC Cancer 10 320

    Article  PubMed  Google Scholar 

  • Kovalszky I, Surmacz E, Scolaro L, Cassone M, Ferla R, Sztodola A, Olah J, Hatfield MP, et al. 2010 Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models. Diabetes Obes. Metab. 12 393–402

    Article  PubMed  CAS  Google Scholar 

  • Macciò A, Madeddu C, Gramignano G, Mulas C, Floris C, Massa D, Astara G, Chessa P, et al. 2010 Correlation of body mass index and leptin with tumor size and stage of disease in hormone-dependent postmenopausal breast cancer: preliminary results and therapeutic implications. J. Mol. Med. (Berl.) 88 677–686

    Article  Google Scholar 

  • McCormack D, Schneider J, McDonald D and McFadden D 2011 The antiproliferative effects of pterostilbene on breast cancer in vitro are via inhibition of constitutive and leptin-induced Janus kinase/signal transducer and activator of transcription activation. Am. J. Surg. 202 541–544

    Article  PubMed  CAS  Google Scholar 

  • McMurtry V, Simeone AM, Nieves-Alicea R and Tari AM 2009 Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells. Clin. Exp. Metastasis 26 197–204

    Article  PubMed  CAS  Google Scholar 

  • McTiernan A 2005 Obesity and cancer: the risks, science, and potential management strategies. Oncology (Williston Park) 19 871–881

    Google Scholar 

  • Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I and Noguchi S 2006 High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int. J. Cancer 118 1414–1419

    Article  PubMed  CAS  Google Scholar 

  • Murthy NS, Mukherjee S, Ray G and Ray A 2009 Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies. J. Postgrad. Med. 55 45–54

    Article  PubMed  CAS  Google Scholar 

  • Nkhata KJ, Ray A, Dogan S, Grande JP and Cleary MP 2009a Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements. Breast Cancer Res. Treat. 114 71–83

    Article  PubMed  CAS  Google Scholar 

  • Nkhata KJ, Ray A, Schuster TF, Grossmann ME and Cleary MP 2009b Effects of adiponectin and leptin co-treatment on human breast cancer cell growth. Oncol. Rep. 21 1611–1619

    PubMed  CAS  Google Scholar 

  • Otvos L Jr and Surmacz E 2011 Targeting the leptin receptor: a potential new mode of treatment for breast cancer. Expert Rev. Anticancer Ther. 11 1147–1150

    Article  PubMed  CAS  Google Scholar 

  • Probst-Hensch NM 2010 Chronic age-related diseases share risk factors: do they share pathophysiological mechanisms and why does that matter? Swiss Med. Wkly. 140 w13072

    PubMed  CAS  Google Scholar 

  • Ray A 2005 Cancer preventive role of selected dietary factors. Indian J. Cancer 42 15–24

    Article  PubMed  Google Scholar 

  • Ray A and Cleary MP 2010 Leptin as a potential therapeutic target for breast cancer prevention and treatment. Expert Opin. Ther. Targets 14 443–451

    Article  PubMed  CAS  Google Scholar 

  • Ray A and Cleary MP 2012 Obesity and breast cancer: A clinical biochemistry perspective. Clin. Biochem. 45 189–197

    Article  PubMed  CAS  Google Scholar 

  • Ray A, Nkhata KJ and Cleary MP 2007a Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status. Int. J. Oncol. 30 1499–1509

    PubMed  CAS  Google Scholar 

  • Ray A, Nkhata KJ, Grande JP and Cleary MP 2007b Diet-induced obesity and mammary tumor development in relation to estrogen receptor status. Cancer Lett. 253 291–300

    Article  PubMed  CAS  Google Scholar 

  • Ray A, Ray GN and Murthy NS 2010 Cancer chemoprevention and lifestyle factors: An overview of epidemiology and biological mechanisms; in Herbal drugs: A cancer chemopreventive and therapeutic perspective (ed) R Arora (New Delhi: Jaypee Brothers Medical Publishers) pp 122–142

    Google Scholar 

  • Rene Gonzalez R, Watters A, Xu Y, Singh UP, Mann DR, Rueda BR and Penichet ML 2009 Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 11 R36

    Article  PubMed  Google Scholar 

  • Rogozina OP, Bonorden MJ, Seppanen CN, Grande JP and Cleary MP 2011 Effect of chronic and intermittent calorie restriction on serum adiponectin and leptin and mammary tumorigenesis. Cancer Prev. Res. (Phila.) 4 568–581

    Article  CAS  Google Scholar 

  • Shpilman M, Niv-Spector L, Katz M, Varol C, Solomon G, Ayalon-Soffer M, Boder E, Halpern Z, et al. 2011 Development and characterization of high affinity leptins and leptin antagonists. J. Biol. Chem. 286 4429–4442

    Article  PubMed  CAS  Google Scholar 

  • Soma D, Kitayama J, Yamashita H, Miyato H, Ishikawa M and Nagawa H 2008 Leptin augments proliferation of breast cancer cells via transactivation of HER2. J. Surg. Res. 149 9–14.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson GD and Rose DP 2003 Breast cancer and obesity: an update. Nutr. Cancer 45 1–16

    Article  PubMed  CAS  Google Scholar 

  • Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, et al. 2011 Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev. Res. (Phila.) 4 329–346

    Article  CAS  Google Scholar 

  • Tam CS, Lecoultre V and Ravussin E 2011 Novel strategy for the use of leptin for obesity therapy. Expert Opin. Biol. Ther. 11 1677–1685

    Article  PubMed  CAS  Google Scholar 

  • Wu MH, Chou YC, Chou WY, Hsu GC, Chu CH, Yu CP, Yu JC and Sun CA 2009 Circulating levels of leptin, adiposity and breast cancer risk. Br. J. Cancer 100 578–582

    Article  PubMed  CAS  Google Scholar 

  • Yu W, Gu JC, Liu JZ, Wang SH, Wang Y, Zhang ZT, Ma XM and Song MM 2010 Regulation of estrogen receptors alpha and beta in human breast carcinoma by exogenous leptin in nude mouse xenograft model. Chin. Med. J. (Engl.) 123 337–343

    CAS  Google Scholar 

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Acknowledgements

I am grateful to Dr Margot P Cleary (Professor, University of Minnesota) for providing an opportunity to work on obesity-related cancer problems. Also I would like to thank my colleague Dr Este Armstrong for useful discussions and critical reading of the manuscript.

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Authors and Affiliations

  1. Saint James School of Medicine, Albert Lake Drive, The Quarter A-1, 2640, Anguilla, British West Indies

    Amitabha Ray

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  1. Amitabha Ray
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Correspondence to Amitabha Ray.

Additional information

MS received 13 September 2011; accepted 02 February 2012

Corresponding editor: Sorab Dalal

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Ray, A. Adipokine leptin in obesity-related pathology of breast cancer. J Biosci 37, 289–294 (2012). https://doi.org/10.1007/s12038-012-9191-9

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