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Hepatitis C in India

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Abstract

Hepatitis C is an emerging infection in India and an important pathogen causing liver disease in India. The high risk of chronicity of this blood-borne infection and its association with hepatocellular carcinoma underscores its public health importance. Blood transfusion and unsafe therapeutic interventions by infected needles are two preventable modalities of spread of hepatitis C infection. In addition, risk factor modification by reducing the number of intravenous drug users will help curtail the prevalence of this infection. This review summarizes the extent, nature and implications of this relatively new pathogen in causing disease in India.

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Abbreviations

ELISA:

Enzyme linked immunosorbent assay

FHF:

fulminant hepatic failure

HBV:

hepatitis B virus

HCV:

hepatitis C virus

HIV:

human immunodeficiency virus

PCR:

polymerase chain reaction

RNA:

ribonucleic acid

SAHF:

sub acute hepatic failure

STD:

sexually transmitted disease

UTR:

untranslated regions

IV:

intravenous

References

  • Acharya S K D S, Kumer T L, Sushma S, Prasanna K S, Tandon A, Sreenivas V, Nijhawan S, Panda S K, Nanda S K, Irshad M, Joshi Y K, Duttagupta S, Tandon R K, Tandon B N 1996 Fulminant hepatitis in a tropical population: clinical course, cause, and early predictors of outcome; Hepatology 23 1448–1455

    Article  CAS  PubMed  Google Scholar 

  • Agarwal M B, Malkan G H, Bhave A A, Vishwanathan C, Billa V, Dube S R, Bajan K, Rajadhyaksha G C and Shah S H 1993 Antibody to hepatitis-C virus in multi-transfused thalassaemics—Indian experience; J. Assoc. Physicians India 41 195–197

    CAS  PubMed  Google Scholar 

  • Agarwal P, Srivastava S, Srivastava M M, Prakash S, Ramanamurthy M, Shrivastav R and Dass S 1997 Studies on leaching of Cr and Ni from stainless steel utensils in certain acids and in some Indian drinks; Sci. Total Environ. 199 271–275

    Article  CAS  PubMed  Google Scholar 

  • Agarwal S K, Dash S C and Irshad M 1999 Hepatitis C virus infection during haemodialysis in India; J. Assoc. Physicians India 47 1139–1143

    CAS  PubMed  Google Scholar 

  • Alter M J, Margolis H S, Krawczynski K, Judson F N, Mares A, Alexander W J, Hu P Y, Miller J K, Gerber M A, Sampliner R E and et al 1992 The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team; N. Engl. J. Med. 327 1899–1905

    Article  CAS  PubMed  Google Scholar 

  • Amarapurkar D D M, Kirpalani A, Amarapurkar A, Kankonkar S 2001 Prevalence of hepatitis C genotypes in Indian patients and their clinical significance; J. Assoc. Physicians India 49 983–985

    CAS  PubMed  Google Scholar 

  • Amarapurkar D N, Kumar A, Vaidya S, Murti P, Bichile S K, Kalro R H and Desai H G 1992 Frequency of hepatitis B, C and D and human immunodeficiency virus infections in multi-transfused thalassemics; Indian J. Gastroenterol. 11 80–81

    CAS  PubMed  Google Scholar 

  • Amarapurkar DN K A, Parikh S S, Chopra K B, Murti P, Kalro R H, Desai H G. 1992 Hepatitis C virus infection in chronic liver disease in Bombay.; Indian J. Gastroenterol. 11 162–162

    CAS  PubMed  Google Scholar 

  • Arankalle V A J J, Favorov M O, Chaudhari A, Fields H A, Banerjee K. 1995 Contribution of HEV and HCV in causing fulminant non-A, non-B hepatitis in western India.; J. Viral. Hepatol. 2 189–193

    Article  CAS  Google Scholar 

  • Arankalle V A, Chadha M S, Jha J, Amrapurkar D N and Banerjee K 1995 Prevalence of anti-HCV antibodies in western India; Indian J. Med. Res. 101 91–93

    CAS  PubMed  Google Scholar 

  • Bendre SV B A, Bhave S A, Pandit A N, Chitambar S D, Arankalle V A 1999 Fulminant hepatic failure: etiology, viral markers and outcome; Indian Pediatr. 36 1107–1112

    CAS  PubMed  Google Scholar 

  • Bhattacharya S, Badrinath S, Hamide A and Sujatha S 2003 Coinfection with hepatitis C virus and human immunodeficiency virus among patients with sexually transmitted diseases in Pondicherry, South India; Indian J. Pathol. Microbiol. 46 495–497

    CAS  PubMed  Google Scholar 

  • Chadha M S, Tungatkar S P and Arankalle V A 1999 Insignificant prevalence of antibodies to hepatitis C in a rural area of western Maharashtra; Indian J. Gastroenterol. 18 22–23

    CAS  PubMed  Google Scholar 

  • Chandra M, Khaja M N, Farees N, Poduri C D, Hussain M M, Aejaz Habeeb M and Habibullah C M 2003 Prevalence, risk factors and genotype distribution of HCV and HBV infection in the tribal population: a community based study in south India; Trop. Gastroenterol. 24 193–195

    PubMed  Google Scholar 

  • Chandra M, Khaja M N, Hussain M M, Poduri C D, Farees N, Habeeb M A, Krishnan S, Ramareddy G V and Habibullah C M 2004 Prevalence of hepatitis B and hepatitis C viral infections in Indian patients with chronic renal failure; Intervirology 47 374–376

    Article  PubMed  Google Scholar 

  • Chandrasekaran S, Palaniappan N, Krishnan V, Mohan G, Chandrasekaran N 2000 Relative prevalence of hepatitis B viral markers and hepatitis C virus antibodies (anti HCV) in Madurai, south India; Indian J. Med. Sci. 54 270–273

    CAS  PubMed  Google Scholar 

  • Chaudhuri S D S, Chowdhury A, Santra A, Bhattacharya S K, Naik T N 2005 Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India; J. Clin. Virol. 32 38–46

    Article  CAS  PubMed  Google Scholar 

  • Choo Q L, Kuo G, Weiner A J, Overby L R, Bradley D W and Houghton M 1989 Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome; Science 244 359–362

    Article  CAS  PubMed  Google Scholar 

  • Chowdhury A, Santra A, Chaudhuri S, Dhali G K, Chaudhuri S, Maity S G, Naik T N, Bhattacharya S K and Mazumder D N 2003 Hepatitis C virus infection in the general population: a community-based study in West Bengal, India; Hepatology 37 802–809

    Article  PubMed  Google Scholar 

  • Cohen J 2007 HIV/AIDS. India slashes estimate of HIV-infected people; Science 317 179–181

    Article  CAS  PubMed  Google Scholar 

  • Das B R K B, Khandapkar R, Sahni S 2002 Geographical distribution of hepatitis C virus genotypes in India.; Indian J. Pathol. Microbiol. 45 323–328

    CAS  PubMed  Google Scholar 

  • Devi Kh S, Brajachand N, Singh H L and Singh Y M 2005 Coinfection by human immuno deficiency virus, hepatitis B and hepatitis C virus in injecting drug users; J. Commun. Dis. 37 73–77

    PubMed  Google Scholar 

  • Donahue J G, Munoz A, Ness P M, Brown D E Jr, Yawn D H, McAllister H A Jr, Reitz B A and Nelson K E 1992 The declining risk of post-transfusion hepatitis C virus infection; N. Engl. J. Med. 327 369–373

    Article  CAS  PubMed  Google Scholar 

  • Fattovich G, Giustina G, Degos F, Tremolada F, Diodati G, Almasio P, Nevens F, Solinas A, Mura D, Brouwer J T, Thomas H, Njapoum C, Casarin C, Bonetti P, Fuschi P, Basho J, Tocco A, Bhalla A, Galassini R, Noventa F, Schalm S W and Realdi G 1997 Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients; Gastroenterology 112 463–472

    Article  CAS  PubMed  Google Scholar 

  • Fattovich G, Stroffolini T, Zagni I and Donato F 2004 Hepatocellular carcinoma in cirrhosis: incidence and risk factors; Gastroenterology 127 S35–S50

    Article  PubMed  Google Scholar 

  • Ganju S A and Goel A 2000 Prevalence of HBV and HCV infection among health care workers (HCWs); J. Commun. Dis. 32 228–230

    CAS  PubMed  Google Scholar 

  • Garg S, Mathur D R, Garg D K 2001 Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India; Indian J. Pathol. Microbiol. 44 409–412

    CAS  PubMed  Google Scholar 

  • Ghosh K, Joshi S H, Shetty S, Pawar A, Chipkar S, Pujari V, Madkaikar M, Pathare A V, Jijina F and Mohanty D 2000 Transfusion transmitted diseases in haemophilics from western India; Indian J. Med. Res. 112 61–64

    CAS  PubMed  Google Scholar 

  • Gosavi M S, Shah S K, Shah S R, Pal R B, Saldanha J A and Banker D D 1997 Prevalence of hepatitis C virus (HCV) infection in Mumbai; Indian J. Med. Sci. 51 378–385

    CAS  PubMed  Google Scholar 

  • Gupta N, Kumar V, Kaur A 2004. Seroprevalence of HIV, HBV, HCV and syphilis in voluntary blood donors; Indian J. Med. Sci. 58 255–257

    PubMed  Google Scholar 

  • Hazra S C, Chatterjee S, Das Gupta S, Chaudhuri U, Jana C K and Neogi D K 2002 Changing scenario of transfusion-related viral infections; J. Assoc. Physicians India 50 879–881

    CAS  PubMed  Google Scholar 

  • Hissar S S G A, Kumar M, Pandey C, Suneetha P V, Sood A, Midha V, Sakhuja P, Malhotra V, Sarin S K 2006 Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease; J. Med. Virol. 78 452–458

    Article  PubMed  Google Scholar 

  • Hoofnagle J H 2002 Course and outcome of hepatitis C; Hepatology 36 S21–S29

    PubMed  Google Scholar 

  • Hussain T, Kulshreshtha K K, Sinha S, Yadav V S and Katoch V M 2006 HIV, HBV, HCV, and syphilis co-infections among patients attending the STD clinics of district hospitals in Northern India; Int. J. Infect. Dis. 10 358–363

    Article  CAS  PubMed  Google Scholar 

  • Irshad M A S 1994 Status of hepatitis viral markers in patients with acute and chronic liver diseases in northern India; Intervirology 37 369–372

    Article  CAS  PubMed  Google Scholar 

  • Irshad M, Acharya S K and Joshi Y K 1995 Prevalence of hepatitis C virus antibodies in the general population & in selected groups of patients in Delhi; Indian J. Med. Res. 102 162–164

    CAS  PubMed  Google Scholar 

  • Issar SK R B, Ramakrishna B, Christopher S, Samuel BU, John TJ. 1995 Prevalence and presentation of hepatitis C related chronic liver disease in southern India.; J. Trop. Med. Hyg. 98 161–165

    CAS  PubMed  Google Scholar 

  • Jain A K P, Madan K, Das U P, Budhiraja S, Gopalkrishna V, Sharma J K, Das B C. 1999 Hepatitis C virus infection in sporadic fulminant viral hepatitis in North India: cause or cofactor?; Eur. J. Gastroenterol. Hepatol. 11 1231–1237

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal S B C D, Asolkar M V, Naik G, Artwani K K 1996 Aetiology and prognostic factors in hepatic failure in central India.; Trop. Gastroenterol. 17 217–220

    CAS  PubMed  Google Scholar 

  • Jaiswal S P, Chitnis D S, Jain A K, Inamdar S, Porwal A and Jain S C 2001 Prevalence of hepatitis viruses among multi-transfused homogenous thalassaemia patients; Hepatol. Res. 19 247–253

    Article  PubMed  Google Scholar 

  • Jaiswal SP C D, Naik G, Artwani K K, Pandit C S, Salgia P, Sepaha A 1996 Prevalence of anti-HCV antibodies in central India.; Indian J. Med. Res. 104 177–181

    CAS  PubMed  Google Scholar 

  • Jha J, Banerjee K and Arankalle V A 1995 A high prevalence of antibodies to hepatitis C virus among commercial plasma donors from Western India; J. Viral. Hepatol. 2 257–260

    Article  CAS  Google Scholar 

  • Kar P B S, Narang A, Chakravarthy A. 1997 Etiology of sporadic acute and fulminant non-A, non-B viral hepatitis in north India.; Indian J. Gastroenterol. 16 43–45

    CAS  PubMed  Google Scholar 

  • Kaur R G R, Berry N, Kar P 2002 Etiology of endemic viral hepatitis in urban North India.; Southeast Asian J. Trop. Med. Public Health. 33 845–848

    PubMed  Google Scholar 

  • Khaja M N, Madhavi C, Thippavazzula R, Nafeesa F, Habib A M, Habibullah C M and Guntaka R V 2006 High prevalence of hepatitis C virus infection and genotype distribution among general population, blood donors and risk groups; Infect. Genet. Evol. 6 198–204

    Article  PubMed  Google Scholar 

  • Khuroo M S D M, Zargar S A, Khan BA, Boda M I, Yattoo G N 1993 Hepatitis C virus antibodies in acute and chronic liver disease in India; J. Hepatol. 17 175–179

    Article  CAS  PubMed  Google Scholar 

  • Liang T J, Rehermann B, Seeff L B and Hoofnagle J H 2000 Pathogenesis, natural history, treatment, and prevention of hepatitis C; Ann. Int. Med. 132 296–305

    Article  CAS  PubMed  Google Scholar 

  • Lole K S J J, Shrotri S P, Tandon B N, Prasad V G, Arankalle V A. 2003 Comparison of hepatitis C virus genotyping by 5′ noncoding region- and core-based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India.; J. Clin. Microbiol. 41 5240–5244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martell M, Esteban J I, Quer J, Genesca J, Weiner A, Esteban R, Guardia J and Gomez J 1992 Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution; J. Virol. 66 3225–3229

    CAS  PubMed  PubMed Central  Google Scholar 

  • Missiha S B, Ostrowski M and Heathcote E J 2008 Disease progression in chronic hepatitis C: modifiable and nonmodifiable factors; Gastroenterology 134 1699–1714

    Article  CAS  PubMed  Google Scholar 

  • Nandi J, Bhawalkar V, Mody H, Elavia A, Desai P K, Banerjee K 1994. Detection of HIV-1, HBV and HCV antibodies in blood donors from Surat, western India; Vox Sang 67 406–407

    Article  CAS  PubMed  Google Scholar 

  • Nanu A, Sharma SP, Chatterjee K, Jyoti P. 1997. Markers for transfusion-transmissible infections in north Indian voluntary and replacement blood donors: prevalence and trends 1989–1996; Vox Sang 73 70–73

    Article  CAS  PubMed  Google Scholar 

  • Neogi D K, Bhattacharya N, Chakrabarti T and Mukherjee K K 1997 HCV activity in Calcutta—a serological study; J. Commun. Dis. 29 1–6

    CAS  PubMed  Google Scholar 

  • Panigrahi A K, Acharya S K, Jameel S, Panda S K 1996 Genotype determination of hepatitis C virus from northern India: identification of a new subtype.; J. Med. Virol. 48 191–198

    Article  CAS  PubMed  Google Scholar 

  • Pawlotsky J M, Penin F, Sablon E, Shin I T, Stuyver L J, Thiel H J, Viazov S, Weiner A J and Widell A 2005 Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes; Hepatology 42 962–973

    Article  PubMed  Google Scholar 

  • Phukan AC S S, Das H K, Mahanta J 2001 HCV activity in an isolated community in north east India.; Indian J. Pathol. Microbiol. 44 403–405

    CAS  PubMed  Google Scholar 

  • Radhakrishnan S, Abraham P, Raghuraman S, John G T, Thomas P P, Jacob C K and Sridharan G 2000 Role of molecular techniques in the detection of HBV DNA & HCV RNA among renal transplant recipients in India; Indian J. Med. Res. 111 204–211

    CAS  PubMed  Google Scholar 

  • Radhika N S, Rajwanshi A, Gupta S K, Sehgal S, Suri S, Chawla Y. 2004 Clinico-cytopathological spectrum of hepatocellular carcinoma, its correlation with serum alpha-fetoprotein level, and hepatitis B and C viral markers; Trop. Gastroenterol. 25 116–120

    PubMed  Google Scholar 

  • Raghuraman S S R, Sridharan G, Radhakrishnan S, Chandy G, Ramakrishna B S, Abraham P 2003 Distribution of the different genotypes of HCV among patients attending a tertiary care hospital in south India; J. Clin. Virol. 26 61–69

    Article  PubMed  Google Scholar 

  • Ramesh R M A and Panda S K 1992 Prevalence of hepatitis C virus antibodies in chronic liver disease and hepatocellular carcinoma patients in India; J. Gastroenterol. Hepatol. 7 393–395

    Article  CAS  PubMed  Google Scholar 

  • Ray G G U, Banerjee P K, Pal B B, Dhar K, Pal A K, Biswas P K 2000 Aetiological spectrum of chronic liver disease in eastern India.; Trop. Gastroenterol. 21 60–62

    CAS  PubMed  Google Scholar 

  • Reddy A K, Murthy K V and Lakshmi V 2005 Prevalence of HCV infection in patients on haemodialysis: survey by antibody and core antigen detection; Indian J. Med. Microbiol. 23 106–110

    Article  CAS  PubMed  Google Scholar 

  • Saha M K, Chakrabarti S, Panda S, Naik T N, Manna B, Chatterjee A, Detels R and Bhattacharya S K 2000 Prevalence of HCV & HBV infection amongst HIV seropositive intravenous drug users & their non-injecting wives in Manipur, India; Indian J. Med. Res. 111 37–39

    CAS  PubMed  Google Scholar 

  • Saravanan S, Velu V, Kumarasamy N, Nandakumar S, Murugavel K G, Balakrishnan P, Suniti S and Thyagarajan S P 2007 Coinfection of hepatitis B and hepatitis C virus in HIV-infected patients in south India; World J. Gastroenterol. 13 5015–5020

    Article  PubMed  PubMed Central  Google Scholar 

  • Sarin S K G R, Banerjee K, Khandekar P 1996 Low prevalence of hepatitis C viral infection in patients with non-alcoholic chronic liver disease in India; J. Assoc. Physicians India. 44 243–245

    CAS  PubMed  Google Scholar 

  • Sarin S K T V, Guptan R C, Saigal S, Malhotra V, Thyagarajan S P, Das B C 2001 Profile of hepatocellular carcinoma in India: an insight into the possible etiologic associations.; J. Gastroenterol. Hepatol. 16 666–673

    Article  CAS  PubMed  Google Scholar 

  • Saxena R T V, Sood B, Guptan R C, Gururaja S, Sarin S K 2000 Transfusion-associated hepatitis in a tertiary referral hospital in India. A prospective study; Vox Sang 79 20

    Article  Google Scholar 

  • Shepard C W, Finelli L and Alter M J 2005 Global epidemiology of hepatitis C virus infection; Lancet Infect. Dis. 5 558–567

    Article  PubMed  Google Scholar 

  • Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M, Murphy D G, Okamoto H, Singh S, Dwivedi S N, Sood R and Wali J P 2000 Hepatitis B, C and human immunodeficiency virus infections in multiply-injected kala-azar patients in Delhi; Scand. J. Infect. Dis. 32 3–6

    Article  Google Scholar 

  • Singh S, Prasad R and Mohanty A 1999 High prevalence of sexually transmitted and blood-borne infections amongst the inmates of a district jail in Northern India; Int. J. STD AIDS 10 475–478

    Article  CAS  PubMed  Google Scholar 

  • Singh S and Sarin S K 2004 Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in India.; Indian J. Med. Res. 119 145–148

    PubMed  Google Scholar 

  • Sonwane BR, Birare SD, Kulkarni PV. 2003. Prevalence of seroreactivity among blood donors in rural population; Indian J. Med. Sci. 57 405–407

    CAS  PubMed  Google Scholar 

  • Sood A S S, Midha V and Jyoti D 1999 High seroprevalence of hepatitis C virus and dual infection (hepatitis B and C virus) in non-alcoholic chronic liver disease in north India; J. Assoc. Physicians India 47 205–208

    CAS  PubMed  Google Scholar 

  • Taga S A, Washington M K, Terrault N, Wright T L, Somberg K A and Ferrell L D 1998 Cholestatic hepatitis C in liver allografts; Liver Transpl. Surg. 4 304–310

    Article  CAS  PubMed  Google Scholar 

  • Tandon B N, Acharya S K, Joshi Y K. 1991 Hepatitis C virus infection is the major cause of severe liver disease in India; Gastroenterol. Jpn. 26 192–195

    Article  PubMed  Google Scholar 

  • Tripathi A K, Khanna M, Gupta N and Chandra M 2007 Low prevalence of hepatitis B virus and hepatitis C virus co-infection in patients with human immunodeficiency virus in Northern India; J. Assoc. Physicians India 55 429–431

    CAS  PubMed  Google Scholar 

  • Valliammai T T S, Zuckerman A J, Harrison T J. 1995 Diversity of genotypes of hepatitis C virus in southern India; J. Gen. Virol. 76 711–716

    Article  CAS  PubMed  Google Scholar 

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Mukhopadhya, A. Hepatitis C in India. J Biosci 33, 465–473 (2008). https://doi.org/10.1007/s12038-008-0065-0

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