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Calpain as a Therapeutic Target for Hypoxic-Ischemic Encephalopathy

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Abstract

Hypoxic-ischemic encephalopathy (HIE) is a complex pathophysiological process with multiple links and factors. It involves the interaction of inflammation, oxidative stress, and glucose metabolism, and results in acute and even long-term brain damage and impairment of brain function. Calpain is a family of Ca2+-dependent cysteine proteases that regulate cellular function. Calpain activation is involved in cerebral ischemic injury, and this involvement is achieved by the interaction among Ca2+, substrates, organelles, and multiple proteases in the neuronal necrosis and apoptosis pathways after cerebral ischemia. Many calpain inhibitors have been developed and tested in the biochemical and biomedical fields. This study reviewed the potential role of calpain in the treatment of HIE and related mechanism, providing new insights for future research on HIE.

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The datasets generated and/or analyzed during the current study are available in the manuscript.

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Authors and Affiliations

  1. Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, China

    Ruiyang Zhao, Xiufei Teng & Yanchao Yang

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  1. Ruiyang Zhao
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  2. Xiufei Teng
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  3. Yanchao Yang
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Contributions

Ruiyang Zhao designed the study and drafted the manuscript. Xiufei Teng and Yanchao Yang collated the data, carried out data analyses, and produced the initial draft of the manuscript. All authors have read and approved the final submitted manuscript.

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Correspondence to Yanchao Yang.

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Zhao, R., Teng, X. & Yang, Y. Calpain as a Therapeutic Target for Hypoxic-Ischemic Encephalopathy. Mol Neurobiol 61, 533–540 (2024). https://doi.org/10.1007/s12035-023-03594-3

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