Abstract
Neuropathic pain (NP) can occur after peripheral nerve injury (PNI), and it can be converted into a maladaptive, detrimental phenotype that causes a long-term state of pain hypersensitivity. In the last decade, the discovery that dysfunctional microglia evoke pain, called “microgliopathic pain,” has challenged traditional neuronal views of “pain” and has been extensively explored. Recent studies have shown that microRNAs (miRNAs) can act as activators or inhibitors of spinal microglia in NP conditions. We first briefly review spinal microglial activation in NP. We then comprehensively describe miRNA expression changes and their potential mechanisms in the response of microglia to nerve injury. We summarize the roles of the following two representative miRNAs: miR-124, which reverses NP by keeping microglia quiescent, and miR-155, which promotes NP following microglial activation. Finally, we focused on the therapeutic potential of microglial miRNAs in NP. The findings we summarized may be essential tools for basic research and clinical treatment of NP.
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Abbreviations
- NP:
-
Neuropathic pain
- PNI:
-
Peripheral nerve injury
- MiRNAs:
-
MicroRNAs
- DRG:
-
Dorsal root ganglion
- CNS:
-
Central nervous system
- 3′-UTRs:
-
3′-Untranslated regions
- CR3:
-
Complement receptor 3
- CD11b:
-
Cluster of differentiation 11b
- Iba-1:
-
Ionized calcium-binding adaptor molecule 1
- POD:
-
Postoperative day
- SNL:
-
Spinal nerve ligation
- SNT:
-
Sciatic nerve transection
- SCI:
-
Spinal cord injury
- CCI:
-
Chronic constriction injury
- TLR:
-
Toll-like recepto
- HDLs:
-
High-density lipoprotein
- SOCS1:
-
Suppressor of cytokine signaling 1
- NOX2:
-
NADPH oxidase
- TNF:
-
Tumor necrosis factor
- p38 MAPKs:
-
Phosphotyrosine 38 mitogen-activated protein kinases
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This work was supported by the grant from the National Natural Science Foundation of China (81870879) and the Natural Science Foundation of Guangdong Province(2017A030313534).
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Jun Zhou conceptualized the review. Simin Tang was a major contributor in writing the manuscript with the help of Huan Jing and Fuhu Song. Haicheng Huang, Wenjun Li, and Guiling Xie drew the figures. All authors read and approved the final manuscript.
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Tang, S., Jing, H., Song, F. et al. MicroRNAs in the Spinal Microglia Serve Critical Roles in Neuropathic Pain. Mol Neurobiol 58, 132–142 (2021). https://doi.org/10.1007/s12035-020-02102-1
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DOI: https://doi.org/10.1007/s12035-020-02102-1