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The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion

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Abstract

Oxidative stress associated with chronic cerebral hypoperfusion is one of the fundamental factors leading to neurodegenerative diseases. To prevent oxidative stress, physical activity is effective. Physical exercise enables development of rehabilitation techniques that can progressively increase patients’ stress resistance. We determined the oxidative stress dynamics in experimental hypoperfusion and modeled rehabilitation measures, comparing sex and stress resistance levels. The experiment was performed on 240 Wistar rats of both sexes over a period of 90 days. Based on behavioral test results obtained using the open field test, the rats were divided into active animals with predicted higher stress resistance (HSR) and passive animals with predicted lower stress resistance (LSR). TBA (thiobarbituric acid) plasma concentration of the active products (malondialdehyde—MDA), blood plasma (NO-X) concentration, and l-citrulline (LC) concentration were determined spectrophotometrically at the corresponding wave length (nm). The intensity of oxidative stress was evaluated using the chemoluminscent method to determine the blood plasma antioxidant activity on the BCL-07 biochemoluminometer. This study revealed two stages of oxidative stress: a less pronounced phase covering the first days after surgery and a main one, which starts from the month after the operation to 3 months. Female sex and a high initial level of stress resistance reduced the severity of oxidative stress. Physical activity commencing a week after the surgery resulted in “reloading” the adaptive mechanisms and slowed the onset of the main stage, leading to a decrease in the free-radical process in all studied subgroups and the greater blood plasma (NO)-X decrease in the male animals. Future neuropharmacological intervention most likely will be able to determine the pathophysiology mechanism of chronic brain hypoperfusion and potentially extending adaptive responses.

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Funding

Part of this study was supported by the IPAC RAS State Targets Project # 0090-2019-0005.. The study was also supported by the Russian Academic Excellence project 5-100 for the Sechenov University, Moscow, Russia.

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Authors and Affiliations

  1. Central Research Laboratory, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, Russian Federation, 153012

    Vladimir V. Chrishtop

  2. Department of Biochemistry, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, Russian Federation, 153012

    Irina K. Tomilova

  3. Department of Human Anatomy, Yaroslavl State Medical University, Street Revolutsionnaya 5, Yaroslavl, Russian Federation, 150000

    Tatiana A. Rumyantseva

  4. I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991

    Elizaveta V. Mikhaylenko, Vladimir N. Nikolenko & Gjumrakch Aliev

  5. Faculty of Health Sciences, Department of Clinic Sciences, University of Tolima, Barrio Santa Helena, Ibagué, 730006, Colombia

    Marco F. Avila-Rodriguez

  6. Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow, Russian Federation, 117418

    Liudmila M. Mikhaleva & Gjumrakch Aliev

  7. Department of Normal and Topographic Anatomy, M.V. Lomonosov Moscow State University, Leninskie Gory, 1, Moscow, Russia, 119991

    Vladimir N. Nikolenko

  8. Department of Biological Sciences, Salem University, Salem, WV, 26426, USA

    Siva G. Somasundaram & Cecil E. Kirkland

  9. Institute of Physiologically Active Compounds of Russian Academy of Sciences, 1 Severny pr., Chernogolovka, Moscow Region, Russia, 142432

    Sergey O. Bachurin & Gjumrakch Aliev

  10. GALLY International Research Institute, 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229, USA

    Gjumrakch Aliev

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  1. Vladimir V. Chrishtop
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Correspondence to Gjumrakch Aliev.

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Animal study: Ethics approval was provided by the Local Ethical Committee, Ivanovo State Medical Academy, in accordance with the International and National Guidelines on conducting studies involving the use of experimental animals. Cervical dislocation was used to euthanize the animals.

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Chrishtop, V.V., Tomilova, I.K., Rumyantseva, T.A. et al. The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion. Mol Neurobiol 57, 3014–3026 (2020). https://doi.org/10.1007/s12035-020-01930-5

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