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Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1

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Abstract

Myelination of axons in the central nervous system is critical for human cognition and behavior. The predominant protein in myelin is proteolipid protein—making PLP1, the gene that encodes for proteolipid protein, one of the primary candidate genes for white matter structure in the human brain. Here, we investigated the relation of genetic variation within PLP1 and white matter microstructure as assessed with myelin water fraction imaging, a neuroimaging technique that has the advantage over conventional diffusion tensor imaging in that it allows for a more direct assessment of myelin content. We observed significant asymmetries in myelin water fraction that were strongest and rightward in the parietal lobe. Importantly, these parietal myelin water fraction asymmetries were associated with genetic variation in PLP1. These findings support the assumption that genetic variation in PLP1 affects white matter myelination in the healthy human brain.

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Acknowledgements

The authors thank Martijn Froeling and PHILIPS Germany for their scientific support with the MRI measurements as well as Tobias Otto for his technical support.

Funding

This work was supported by the Deutsche Forschungsgemeinschaft (DFG) grant numbers Gu227/16-1 and GE2777/2-1 and the MERCUR foundation grant number An-2015-0044.

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Author notes

  1. Sebastian Ocklenburg, Catrona Anderson and Wanda M. Gerding contributed equally to this work.

Authors and Affiliations

  1. Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr University Bochum, Bochum, Germany

    Sebastian Ocklenburg, Catrona Anderson, Christoph Fraenz, Caroline Schlüter, Patrick Friedrich, Onur Güntürkün & Erhan Genç

  2. Department of Psychology, University of Otago, Dunedin, New Zealand

    Catrona Anderson

  3. Department of Human Genetics, Ruhr University Bochum, Bochum, Germany

    Wanda M. Gerding, Larissa Arning & Jörg T. Epplen

  4. Faculty of Health, ZBAF, University of Witten/Herdecke, Witten, Germany

    Maximilian Raane & Jörg T. Epplen

  5. Philips GmbH, Hamburg, Germany

    Burkhard Mädler

  6. Department of Neurology, BG-University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany

    Lara Schlaffke

  7. Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany

    Christian Beste

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  1. Sebastian Ocklenburg
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Correspondence to Sebastian Ocklenburg.

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The study was approved by the local ethics committee of the Faculty of Psychology at Ruhr University Bochum. All participants gave their written informed consent and were treated in accordance with the Declaration of Helsinki.

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Ocklenburg, S., Anderson, C., Gerding, W.M. et al. Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1. Mol Neurobiol 56, 3999–4012 (2019). https://doi.org/10.1007/s12035-018-1351-y

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